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Table 2 The frequencies of detected resistance alleles in each of the 4 patients after drug resistance. None of these mutations were observed (below detection limit) in the populations prior to development of resistance

From: Single-virion sequencing of lamivudine-treated HBV populations reveal population evolution dynamics and demographic history

# Mutation Pooled Deep Seq BAsE-Seq PacBio
P1 M204 V L180 M M204I 0.525 0.560 0.457 0.711 0.752 0.251 0.567 0.611 0.358
P2 M204I 0.978 0.882 0.990
P7 M204 V L180 M   0.870 0.946  
P11 M204I L180 M   0.948 0.679