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Table 2 The frequencies of detected resistance alleles in each of the 4 patients after drug resistance. None of these mutations were observed (below detection limit) in the populations prior to development of resistance

From: Single-virion sequencing of lamivudine-treated HBV populations reveal population evolution dynamics and demographic history

# Mutation Pooled Deep Seq BAsE-Seq PacBio
P1 M204 V
L180 M
M204I
0.525
0.560
0.457
0.711
0.752
0.251
0.567
0.611
0.358
P2 M204I 0.978 0.882 0.990
P7 M204 V
L180 M
  0.870
0.946
 
P11 M204I
L180 M
  0.948
0.679