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Table 2 Fifteen selected SNPs in relation to hs-GH in GWAS-approach in MDC-CC

From: Genetic determinants of growth hormone and GH-related phenotypes

SNP

Chr

Basepaira

Major allele

Minor allele

MAF

Geneb

β

95%CI

P

rs7920826

10

122,808,053

T

G

0.16

−0.19

−0.27 to −0.11

4.2a10^-6

rs9816337

3

28,936,109

G

T

0.46

−0.14

−0.20 to −0.08

4.3a10^-6

rs7208736

17

1,807,705

G

A

0.36

−0.14

−0.21 to −0.08

5.2a10^-6

rs6552287

4

179,194,375

T

C

0.42

−0.14

−0.20 to −0.08

5.2a10^-6

rs10513091

5

11,423,525

T

C

0.15

CTNND2

0.19

0.11 to 0.27

6.5a10^-6

rs11644234

16

53,036,844

C

T

0.11

−0.21

−0.30 to −0.11

1.1a10^-5

rs3803071

12

94,698,880

T

C

0.45

PLXNC1

−0.13

−0.19 to −0.07

1.3a10^-5

rs10472071

5

58,031,027

A

G

0.09

RAB3C

0.22

0.11 to 0.32

5.3a10^-5

rs17094404

8

13,370,143

T

C

0.03

DLC1

0.26

0.09 to 0.42

0.003

rs7987689

13

43,928,135

C

T

0.34

ENOX1

−0.09

−0.15 to −0.03

0.005

rs4839595

3

143,163,169

G

A

0.45

SLC9A9

0.08

0.02 to 0.14

0.008

rs6767160

3

71,741,068

T

C

0.06

EIF4E3

0.15

0.02 to 0.28

0.018

rs687543

5

81,220,187

C

T

0.10

−0.12

−0.21 to −0.02

0.019

rs2361028

1

119,410,215

G

T

0.45

0.04

−0.02 to 0.10

0.14

rs16961034

16

59,419,461

T

C

0.01

0.30

0.03 to 0.57

0.030

  1. Minor allele modeled as effect allele.The β coefficients are expressed as the increment of standardized values of the natural logarithm of hs-GH per 1 minor allele. Adjusted for age and sex
  2. Abbreviations: chr Chromosome number, MAF Minor allele frequency, Gene Annotated gene. No available for analysis in: all: 4123–4134
  3. abasepair positions refer to GRCh37
  4. bGene annotation