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Table 2 Fifteen selected SNPs in relation to hs-GH in GWAS-approach in MDC-CC

From: Genetic determinants of growth hormone and GH-related phenotypes

SNP Chr Basepaira Major allele Minor allele MAF Geneb β 95%CI P
rs7920826 10 122,808,053 T G 0.16 −0.19 −0.27 to −0.11 4.2a10^-6
rs9816337 3 28,936,109 G T 0.46 −0.14 −0.20 to −0.08 4.3a10^-6
rs7208736 17 1,807,705 G A 0.36 −0.14 −0.21 to −0.08 5.2a10^-6
rs6552287 4 179,194,375 T C 0.42 −0.14 −0.20 to −0.08 5.2a10^-6
rs10513091 5 11,423,525 T C 0.15 CTNND2 0.19 0.11 to 0.27 6.5a10^-6
rs11644234 16 53,036,844 C T 0.11 −0.21 −0.30 to −0.11 1.1a10^-5
rs3803071 12 94,698,880 T C 0.45 PLXNC1 −0.13 −0.19 to −0.07 1.3a10^-5
rs10472071 5 58,031,027 A G 0.09 RAB3C 0.22 0.11 to 0.32 5.3a10^-5
rs17094404 8 13,370,143 T C 0.03 DLC1 0.26 0.09 to 0.42 0.003
rs7987689 13 43,928,135 C T 0.34 ENOX1 −0.09 −0.15 to −0.03 0.005
rs4839595 3 143,163,169 G A 0.45 SLC9A9 0.08 0.02 to 0.14 0.008
rs6767160 3 71,741,068 T C 0.06 EIF4E3 0.15 0.02 to 0.28 0.018
rs687543 5 81,220,187 C T 0.10 −0.12 −0.21 to −0.02 0.019
rs2361028 1 119,410,215 G T 0.45 0.04 −0.02 to 0.10 0.14
rs16961034 16 59,419,461 T C 0.01 0.30 0.03 to 0.57 0.030
  1. Minor allele modeled as effect allele.The β coefficients are expressed as the increment of standardized values of the natural logarithm of hs-GH per 1 minor allele. Adjusted for age and sex
  2. Abbreviations: chr Chromosome number, MAF Minor allele frequency, Gene Annotated gene. No available for analysis in: all: 4123–4134
  3. abasepair positions refer to GRCh37
  4. bGene annotation