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Table 2 MIC (μg/ml) of different antibiotics for B. cenocepacia J2315, D4, D4(pEP_RND4_operon), D4(pEP_RND2_operon), J2315(pEP_RND4_operon), J2315(pEP_RND2_operon), D4/C18 and D4/C20 strains

From: Subfunctionalization influences the expansion of bacterial multidrug antibiotic resistance

B.cenocepacia strain Quinolones/Fluoroquinolones Aminoglycosides Ansamycins β_lactams Macrolides Tetracyclines Drug against mycobacteria Others
CIP LEV NOR SPAR NAL A KAN STREP AMP ERY TET RIF CHL GRAM NOV
J2315 4 8 16–32 8 16–32 2000 >4000 >4000 500 128 256 64 >512 16
D4 2 2 8 4 8 2000 4000 >4000 500 64 64–128 16 >512 <1
D4 (pEP_RND4_operon) 2–4 4 16 8 32 2000 4000 >4000 500 128 256 64 >512 16
D4 (pEP_RND2_operon) 4 4 16 4 64 2000 2000 >4000 500 64–128 128–256 128 >512 8
J2315 (pEP_RND4_operon) 8 8 32 8 32 2000 4000 >4000 500 128 256 128 >512 32
J2315 (pEP_RND2_operon) 4 8 16 8 32 2000 4000 >4000 500 128 256 64 >512 16
D4/C18 8 8 128 4 256 2000 4000 >4000 500 64 64–128 512 >512 64
D4/C20 8 8 32 4 256 2000 4000 >4000 500 64 64–128 512 >512 64
  1. Abbreviation: CIP ciprofloxacin, LEV levofloxacin, NOR norfloxacin, SPAR sparfloxacin, NAL A nalidixic acid, KAN kanamycin, STREP streptomycin, AMP ampicillin, ERY erythromycin, TET tetracycline, RIF rifampicin, CHL chloramphenicol, GRAM gramidicin, NOV novobiocin
  2. Strains information: D4 = ΔRND4 operon; D4 (pEP_RND4_operon) = D4 with the addition of RND4 operon, D4 (pEP_RND2_operon) = D4 with the addition of RND2 operon, J2315 (pEP_RND4_operon) = J2315 with the addition of RND4 operon, J2315 (pEP_RND2_operon) = J2315 with the addition of RND2 operon, D4/C18 and D4/C20 = D4 derived mutant strains, selected on CAF