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Fig. 5 | BMC Genomics

Fig. 5

From: Genome-wide DNA methylation profiling reveals novel epigenetic signatures in squamous cell lung cancer

Fig. 5

Validation of selected methylation biomarkers. a Clinical validation of DNA methylation levels of selected genes in paired LUSC and adjacent NTL tissue by using pyrosequencing. b Clinical validation of mRNA expression of selected genes in paired LUSC and adjacent NTL tissue by using qRT-PCR. c ROC curves and area under the curve (AUC) for the candidate genes. Sensitivity, Specificity and the optimal cut-off values were marked in the figures. *** corresponds to p < 0.001; ** p < 0.01 and * p < 0.05

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