Fig. 1
From: Unraveling the evolution and coevolution of small regulatory RNAs and coding genes in Listeria
Strategy and workflow. The strategy consists in 4 steps: (1) Construction of a phylogenetic reference tree computed from a super-alignment of syntenic core genes and a Maximum Likelihood approach (2) Presence-absence matrices computation using alignments of sRNAs, 5’UTRs and CDS (3) Ancestral presence-absence pattern reconstruction for sRNAs, 5’UTRs and CDS based on Markov Model and a Maximum Likelihood approach (4) Detection of coevolution events between sRNAs and 5’UTRs or CDS using both observed and ancestral patterns and construction of the sRNA-coding genes coevolution network