Transcriptomics, metabolomics and histology indicate that high-carbohydrate diet negatively affects the liver health of blunt snout bream (Megalobrama amblycephala)

Prisingkorn, Wassana; Prathomya, Panita; Jakovlić, Ivan; Liu, Han; Zhao, Yu-Hua; Wang, Wei-Min

doi:10.1186/s12864-017-4246-9

Table 2 Differentially expressed genes in liver transcriptome profiles of control and HCBD groups associated with non-alcoholic fatty liver disease pathway (^a) and insulin signaling pathway (^b) in KEGG database

From: Transcriptomics, metabolomics and histology indicate that high-carbohydrate diet negatively affects the liver health of blunt snout bream (Megalobrama amblycephala)

Gene Name	KEGG Number	Nr_annotation	FDR	log2FC	Regulation
SOCS3^a,b	K04696	Suppressor of cytokine signaling 3b (Danio rerio)	0.009144	−2.802	Down
INSR^a,b	K04527	Insulin receptor a precursor (Danio rerio)	0.272547	1.070	Up
IRS^a,b	K07187	Insulin receptor substrate 2-B-like (Danio rerio)	0.013461	1.903	Up
PI3K^a,b	K02649	Phosphatidylinositol 3-kinase regulatory subunit beta, partial (Anas platyrhynchos)	0.048268	−5.230	Down
PDK1^b	K06276	3-phosphoinositide-dependent protein kinase 1 isoform X1 (Danio rerio)	0.050913	1.603	Up
Akt^a,b	K04456	RAC-gamma serine/threonine-protein kinase (Danio rerio)	0.000433	6.580	Up
GSK3^a,b	K03083	Glycogen synthase kinase-3 beta-like (Lepisosteus oculatus)	3.08E-13	−8.657	Down
GSK3^a,b	K03083	Glycogen synthase kinase-3 beta-like isoform X3 (Neolamprologus brichardi)	0.002352	−6.405	Down
AMPK^a,b	K07198	MAP/microtubule affinity-regulating kinase 3 (Danio rerio)	8.08E-13	−8.608	Down
	K07198	MAP/microtubule affinity-regulating kinase 3 (Esox lucius)	0.038900	−5.459	Down
	K07198	Serine/threonine-protein kinase MARK1-like (Stegastes partitus)	0.012837	−5.540	Down
ACC^b	K11262	Acetyl-CoA carboxylase 2 isoform X2 (Danio rerio)	1	0.369	Up
AP-1^a	K04448	Transcription factor AP-1 (Oncorhynchus mykiss)	5.72E-05	6.614	Up
PEPCK^b	K01596	Phosphoenolpyruvate carboxykinase (Acanthopagrus schlegelii)	0.002169	5.994	Up
FBP^b	K03841	Fructose-1,6-bisphosphatase 1-like (Xiphophorus maculatus)	0.007951	6.039	Up
	K03841	Fructose-1,6-bisphosphatase 1-like isoform X3 (Cynoglossus semilaevis)	0.007492	6.142	Up
	K03841	Fructose-1,6-bisphosphatase 1-like (Poecilia reticulata)	1.95E-10	−8.129	Down
	K03841	Fructose-1,6-bisphosphatase 1-like (Oryzias latipes)	0.020039	−5.485	Down
	K03841	Fructose-1,6-bisphosphatase 1-like (Poecilia formosa)	0.040649	−5.577	Down

^aNon-alcoholic fatty liver disease pathway (ko04932), ^bInsulin signaling pathway (ko04910)

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