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Table 3 The results of GO and KEGG pathway enrichment analysis for genes clustered in coral1 module

From: Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI

Category

Term

Gene Symbol

Corrected P-value

Gene Ontology term--Biological Process

Positive regulation of phospholipase activity (GO:0010518)

CYR61; APOC2*

2.91E-03

Gene Ontology term--Biological Process

High-density lipoprotein particle clearance (GO:0034384)

APOC2*; APOE*

4.36E-03

Gene Ontology term--Biological Process

Chylomicron remnant clearance (GO:0034382)

APOC2*; APOE*

4.36E-03

Gene Ontology term--Biological Process

Phospholipid efflux (GO:0033700)

APOE*; APOC2*

1.30E-02

Gene Ontology term--Biological Process

Reverse cholesterol transport (GO:0043691)

APOC2*; APOE*

2.24E-02

Gene Ontology term--Biological Process

Positive regulation of axon extension (GO:0045773)

APOE*; RAB25

2.61E-02

Gene Ontology term--Cellular Component

Intermediate-density lipoprotein particle (GO:0034363)

KCNJ1; KCNT1*; KCNA1

2.74E-03

Gene Ontology term--Cellular Component

Chylomicron (GO:0042627)

APOE*; APOC2*

9.97E-03

Gene Ontology term--Cellular Component

Voltage-gated potassium channel complex (GO:0008076)

TBX2*; LBX1*; SOX18*

1.43E-02

Gene Ontology term--Cellular Component

Low-density lipoprotein particle (GO:0034362)

TRH; GAL*

1.89E-02

Gene Ontology term--Cellular Component

Very-low-density lipoprotein particle (GO:0034361)

APOC2*; APOE*

2.74E-02

Gene Ontology term--Cellular Component

Dendrite (GO:0030425)

MYO1A; NKD2

3.63E-02

Gene Ontology term--Molecular Function

Cholesterol transporter activity (GO:0017127)

ABCG4*; APOE*

9.72E-03

Gene Ontology term--Molecular Function

Neuropeptide hormone activity (GO:0005184)

GAL*; TRH

1.98E-02

KEGG pathway

Alcoholism (ko05034)

SHC2; GRIN2C; HIST3H2BB

1.79E-02

KEGG pathway

Cell adhesion molecules (CAMs) (ko04514)

SDC1; CADM3; CLDN6

2.00E-02

  1. Note: * represents the hub genes in coral1 module