Skip to main content
Fig. 3 | BMC Genomics

Fig. 3

From: Meta-analysis of sequence-based association studies across three cattle breeds reveals 25 QTL for fat and protein percentages in milk at nucleotide resolution

Fig. 3

Meta-analysis of fat and protein percentages in milk across three cattle breeds. (a) Composite manhattan plot that shows the association of 26,473,121 imputed sequence variants with FP and PP in the meta-analysis. The composite manhattan plot summarizes the results of the meta-analyses, i.e., each dot shows the more significant P value that was observed across both traits. Red colours represent sequence variants with P values less than 1e-8. The y-axis is truncated at –log10(1e-40). (b) Quantile-quantile plot of the meta-analyses. Grey and cyan colour represent P values of 26,473,121 imputed sequence variants for FP and PP, respectively. The y-axis is truncated at –log10(1e-10). (c) Overview of 25 QTL that were significant at P < 1e-8 in the meta-analysis and within-breed association studies. Filled squares indicate that QTL were significant in the respective analysis. The labels at the x-axis represent the positon of the top variant at each QTL. (d) Allelic substitution effects of 25 OTL on FP and PP. The QTL effects are given in phenotypic standard deviations. Bold type indicates three causal missense mutations in the ABCG2, DGAT1 and GHR genes

Back to article page