Table 5 Enriched genetic pathways between Restricted Anovulatory and Restricted Ovulatory groups from Innatedb
Pathway name | Genes | Total no. of genes in pathway | P value |
|---|---|---|---|
Neuroactive ligand-receptor interaction | PACA ↑, AGRP ↑, AGTR1 ↓, A6QL98 ↑, A4IFF5 ↑, CALRL ↑, A6QHL2 ↑, Q9BGU4 ↓, C6KEA7 ↑, PAR1 ↑, A6QQP6 ↑, GBRR2 ↓, GHR ↑, SLIB ↑, GPR83 ↑, GRIK3 ↓, GRIN2A ↓, GRIN2B ↓, GRIN2C ↓, GRM4 ↓, HRH1 ↑, 5HT2A ↑, MC4R ↑, NPY ↑, NTSR1 ↓, TRY2 ↑, PF2R ↑, S1PR5 ↓, TKN1 ↑, TSHR ↑ | 301 | 0.000211925 |
Toll-like receptor signaling pathway | Q2LGB8 ↑, CD14 ↑, Q1JPC5 ↑, CXL10 ↑, CXCL9 ↑, FADD ↓, IL1B ↑, A6QQK2 ↓, PIK3CD ↓, A4IFU4 ↑, TLR2 ↑, TLR3 ↑, TLR4 ↑ | 101 | 0.00365653 |
Caspase8 activation signalling | Q2LGB8 ↑, FADD ↓ | 2 | 0.004011647 |
Systemic lupus erythematosus | Q3SYT3 ↑, C1S ↑, Q1JPC5 ↑, FCGR2 ↑, FCGR3 ↑, GRIN2A ↓, GRIN2B ↓, Q17QG8 ↓, RO52 ↑ | 95 | 0.004188484 |
Signaling by GPCR | ADCY1 ↓, PACA ↑, AGTR1 ↓, A6QL98 ↑, ARHGEF1 ↓, CALRL ↑, A6QHL2 ↑, CCR5 ↑, Q9BGU4 ↓, C6KEA7 ↑, CXL10 ↑, CXCL9 ↑, PAR1 ↑, SLIB ↑, A2VEA2 ↓, GRM4 ↓, HRH1 ↑, 5HT2A ↑, MC4R ↑, NPY ↑, NTSR1 ↓, OR2W3 ↓, PDE8B ↑, LOC785870 ↑, LOC616798 ↓, PF2R ↑, RGR ↓, S1PR5 ↓, TKN1 ↑, TSHR ↑ | 648 | 0.004475761 |
Class A/1 (Rhodopsin-like receptors) | AGTR1 ↓, A6QL98 ↑, A6QHL2 ↑, CCR5 ↑, CXL10 ↑, CXCL9 ↑, PAR1 ↑, A2VEA2 ↓, HRH1 ↑, 5HT2A ↑, MC4R ↑, NPY ↑, NTSR1 ↓, LOC785870 ↑, PF2R ↑, RGR ↓, S1PR5 ↓, TKN1 ↑, TSHR ↑ | 222 | 0.006932285 |