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Fig. 2 | BMC Genomics

Fig. 2

From: ENCoRE: an efficient software for CRISPR screens identifies new players in extrinsic apoptosis

Fig. 2

The User Interface of ENCoRE. ENCoRE comprises two modules: the FASTQ Filter Module (FFM) and the CRISPR Report Module (CRM). The FFM (left) is used to curate primary FASTQ sequencing files and to remove extraneous sequences, leaving CRISPR guide sequences intact. Workflows can be saved to maintain processing fidelity between multiple files. The CRM (right) compares guides to a reference file to generate designations (for example, gene, chromosomal location) according to user. The resulting absolute guide representation is displayed in form of a configurable pie chart, with the option to aggregate guides directed against a given target. Illustrative results are shown here for the TNFa challenge described below

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