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Fig. 4 | BMC Genomics

Fig. 4

From: ENCoRE: an efficient software for CRISPR screens identifies new players in extrinsic apoptosis

Fig. 4

Challenge of mutant cell lines to different cell death stimuli. The control (parental) cell line as well as individually engineered null mutant cell lines (Smg7, Ces2a, Hnrnpf, Tnfrsf1a) were compared for resistance to a panel of cell death inducing agents. Two-way, repeated-measures ANOVA with a Bonferroni post test showed Smg7 and Ces2a mutant cell lines to be statistically different from control cells at different doses (colored asterisks: above, more resistant; below, more sensitive. Statistics of other cell lines not shown). *P < .05. **P < .01. ***P < .001. Z-Val-Ala-Asp-fluoromethylketone (zVAD) was added to control cells to demonstrate caspase-dependent cell death. Abbreviations: Deoxycholic acid (DCA); 5-Fluorouracil, (5-FU)

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