Fig. 1
From: Genome-wide segregation of single nucleotide and structural variants into single cancer cells
Overview of Experimental Protocol and Performance. a Whole genome sequencing is first performed to determine the comprehensive mutation profile of the sample, followed by variant confirmation using targeted resequencing. Single cells are then isolated, followed by amplification of the variant sites, variant calling, and binary matrix construction to determine the clonal structure. b Overview of putative variant site coverage and confirmation rates. c Class and size of confirmed structural variants