Fig. 2

Childhood Leukemia Example. a Heatmap depicting clustering patterns of cells and mutations. Three clear mutation clusters segregate into two distinct clonal populations. The ancestral shared mutation cluster is composed entirely of structural variants. b Minimal spanning tree showing the relative size of and genetic distance between each clone. Known driver mutations are depicted in red, immune receptor rearrangements in orange, and putative drivers of clonal expansions in black. The relative contribution of single nucleotide and structural variation to each clone are also represented by the pie charts adjacent to each clone