Fig. 2

Principal component analysis (PCA) plot (a) of overall mRNA expression data that characterize the entire testicular transcriptional profile of enrolled samples. Each cube represents one single microarray of FL2 (orange) and Ctrl (green) mice. The PCA plot was generated using Affymetrix Expression Console software. Unsupervised hierarchical cluster analysis (b) of the 500 most differentially expressed genes over all groups performed. Genes are indicated vertically, the individual testicular samples are designated horizontally (FL2 orange; Ctrl green). Genes displaying upregulation are visualized in red-, genes showing downregulation are specified in blue. Intensity of the red or blue color suggests signal intensity as annotated in the scale