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Table 2 Genes encoding regulatory proteinsa which are up- or down-regulated in S. clavuligerus pSCL4-

From: Discovering the potential of S. clavuligerus for bioactive compound production: cross-talk between the chromosome and the pSCL4 megaplasmid

Gene

Product

Mc

BH-corrected P-value

Fold change

22.5 h

46.5 h

60 h

22.5 h

46.5 h

60 h

22.5 h

46.5 h

60 h

Up-regulated

 SCLAV_2377

ECF-subfamily RNA polymerase sigma factor

2.42

1.91

1.76

1.80E-05

1.43E-04

2.61E-04

5.36

3.77

3.39

 SCLAV_2378

Lipoprotein cseA

1.30

0.83

1.23

1.55E-05

1.08E-03

8.98E-06

2.46

1.77

2.35

 SCLAV_2379

Transcriptional regulatory protein cseB

1.34

1.08

1.71

1.35E-03

6.52E-03

5.56E-05

2.54

2.11

3.26

 SCLAV_2380

Sensor protein

1.60

1.22

2.19

6.07E-04

5.17E-03

9.20E-06

3.04

2.33

4.56

 SCLAV_3934

Alkyl hydroperoxide reductase ahpD

0.61

1.24

3.66

3.34E-01

2.15E-02

2.27E-07

1.53

2.37

12.63

 SCLAV_3935

Alkyl hydroperoxide reductase

0.57

1.27

3.90

3.35E-01

1.29E-02

3.82E-08

1.49

2.41

14.89

 SCLAV_3936

Putative LysR-family transcriptional regulator

1.11

1.48

2.06

1.47E-02

1.09E-03

2.09E-05

2.16

2.79

4.17

 SCLAV_4082

RNA polymerase sigma factor RpoE

1.23

1.64

0.66

2.61E-03

1.06E-04

8.26E-02

2.35

3.11

1.58

 SCLAV_4083

Putative anti-sigma factor

1.06

1.30

0.29

4.63E-03

5.29E-04

4.56E-01

2.08

2.46

1.22

Down-regulated

 SCLAV_0691

RNA polymerase sigma factor

1.35

1.62

1.21

2.66E-03

3.19E-04

3.78E-03

2.55

3.08

2.32

 SCLAV_2573

WhiB-family transcriptional regulator

2.74

3.47

4.47

6.05E-04

3.12E-05

9.92E-07

6.68

11.11

22.16

 SCLAV_2833

Putative serine/threonine kinase anti-sigma factor

1.16

1.70

2.54

4.77E-02

2.92E-03

3.22E-05

2.24

3.24

5.81

 SCLAV_3047

Predicted transcriptional regulator

1.43

2.74

2.45

2.53E-02

5.41E-05

1.40E-04

2.69

6.70

5.47

 SCLAV_3146

TetR-family transcriptional regulator

1.04

1.20

1.55

5.19E-03

1.16E-03

5.07E-05

2.06

2.29

2.93

 SCLAV_3422

Transcriptional regulator

1.80

2.65

3.79

3.07E-02

1.37E-03

2.01E-05

3.49

6.27

13.82

 SCLAV_3814

ECF-subfamily RNA polymerase sigma factor

1.27

1.08

1.71

5.63E-03

1.38E-02

1.94E-04

2.42

2.11

3.27

 SCLAV_4929

Regulatory protein

1.71

1.98

3.90

7.07E-03

1.64E-03

1.49E-06

3.28

3.94

14.92

  1. aOnly some of the most affected genes are shown