Discovering the potential of S. clavuligerus for bioactive compound production: cross-talk between the chromosome and the pSCL4 megaplasmid

Rubén Álvarez-Álvarez; Yolanda Martínez-Burgo; Antonio Rodríguez-García; Paloma Liras

doi:10.1186/s12864-017-4289-y

BMC Genomics

Table 2 Genes encoding regulatory proteins^a which are up- or down-regulated in S. clavuligerus pSCL4^-

From: Discovering the potential of S. clavuligerus for bioactive compound production: cross-talk between the chromosome and the pSCL4 megaplasmid

Gene	Product	M_c			BH-corrected P-value			Fold change
Gene	Product	22.5 h	46.5 h	60 h	22.5 h	46.5 h	60 h	22.5 h	46.5 h	60 h
Up-regulated
SCLAV_2377	ECF-subfamily RNA polymerase sigma factor	2.42	1.91	1.76	1.80E^-05	1.43E^-04	2.61E^-04	5.36	3.77	3.39
SCLAV_2378	Lipoprotein cseA	1.30	0.83	1.23	1.55E^-05	1.08E^-03	8.98E^-06	2.46	1.77	2.35
SCLAV_2379	Transcriptional regulatory protein cseB	1.34	1.08	1.71	1.35E^-03	6.52E^-03	5.56E^-05	2.54	2.11	3.26
SCLAV_2380	Sensor protein	1.60	1.22	2.19	6.07E^-04	5.17E^-03	9.20E^-06	3.04	2.33	4.56
SCLAV_3934	Alkyl hydroperoxide reductase ahpD	0.61	1.24	3.66	3.34E^-01	2.15E^-02	2.27E^-07	1.53	2.37	12.63
SCLAV_3935	Alkyl hydroperoxide reductase	0.57	1.27	3.90	3.35E^-01	1.29E^-02	3.82E^-08	1.49	2.41	14.89
SCLAV_3936	Putative LysR-family transcriptional regulator	1.11	1.48	2.06	1.47E^-02	1.09E^-03	2.09E^-05	2.16	2.79	4.17
SCLAV_4082	RNA polymerase sigma factor RpoE	1.23	1.64	0.66	2.61E^-03	1.06E^-04	8.26E^-02	2.35	3.11	1.58
SCLAV_4083	Putative anti-sigma factor	1.06	1.30	0.29	4.63E^-03	5.29E^-04	4.56E^-01	2.08	2.46	1.22
Down-regulated
SCLAV_0691	RNA polymerase sigma factor	⁻1.35	⁻1.62	⁻1.21	2.66E^-03	3.19E^-04	3.78E^-03	2.55	3.08	2.32
SCLAV_2573	WhiB-family transcriptional regulator	⁻2.74	⁻3.47	⁻4.47	6.05E^-04	3.12E^-05	9.92E^-07	6.68	11.11	22.16
SCLAV_2833	Putative serine/threonine kinase anti-sigma factor	⁻1.16	⁻1.70	⁻2.54	4.77E^-02	2.92E^-03	3.22E^-05	2.24	3.24	5.81
SCLAV_3047	Predicted transcriptional regulator	⁻1.43	⁻2.74	⁻2.45	2.53E^-02	5.41E^-05	1.40E^-04	2.69	6.70	5.47
SCLAV_3146	TetR-family transcriptional regulator	⁻1.04	⁻1.20	⁻1.55	5.19E^-03	1.16E^-03	5.07E^-05	2.06	2.29	2.93
SCLAV_3422	Transcriptional regulator	⁻1.80	⁻2.65	⁻3.79	3.07E^-02	1.37E^-03	2.01E^-05	3.49	6.27	13.82
SCLAV_3814	ECF-subfamily RNA polymerase sigma factor	⁻1.27	⁻1.08	⁻1.71	5.63E^-03	1.38E^-02	1.94E^-04	2.42	2.11	3.27
SCLAV_4929	Regulatory protein	⁻1.71	⁻1.98	⁻3.90	7.07E^-03	1.64E^-03	1.49E^-06	3.28	3.94	14.92

^aOnly some of the most affected genes are shown

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