The insect pathogenic bacterium Xenorhabdus innexi has attenuated virulence in multiple insect model hosts yet encodes a potent mosquitocidal toxin

Table 6 NPRS, PKS, and NPRS-PKS hybrid clusters in the X. innexi genome

Location	Size (bp)	Type	Number of A or AT domains^a
XIS1_130014	5139	PKS^b	1 AT domain
XIS1_250010	13,755	NRPS^c	6 A domains
XIS1_40005 - XIS1_60002	21,138	NPRS	4 A domains
XIS1_170001 - XIS1_190004	21,111	NPRS	6 A domains
XIS1_370002 - XIS1_370004	15,468	NPRS	3 A domains
XIS1_390007 - XIS1_400001	15,519	NPRS	5 A domains
XIS1_450016	2997	NRPS	1 A domain
XIS1_460014	7323	NPRS	2 A domains
XIS1_460105 - XIS1_460116	44,193	Hybrid^d	6 A domains and 2 AT domains
XIS1_480023 - XIS1_480027	23,055	Hybrid	3 A domains and 1 AT domain
XIS1_600036	3060	NRPS	1 A domain
XIS1_660020 - XIS1_660029	21,609	Hybrid	3 A domains and 1 AT domain
XIS1_1050018 - XIS1_1050019	3366	NRPS	1 A domain
XIS1_1690009 - XIS1_1690010	23,319	NRPS	7 A domains
XIS1_1700078	11,811	NRPS	3 A domains
XIS1_1750018 - XIS1_1750021	44,826	NRPS	13 A domains

^aA domain; Adenylation domain, AT domain; Acyltransferase domain predicted by antiSMASH
^bPKS; Polyketide synthase
^cNRPS; Non-ribosomal peptide synthetase
^dHybrid; NRPS-PKS hybrid gene

ISSN: 1471-2164