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Table 2 Enriched functions of DE genes in Down and Up group using IPA (89% grain vs. 72% grain)

From: Transcriptome analysis of ruminal epithelia revealed potential regulatory mechanisms involved in host adaptation to gradual high fermentable dietary transition in beef cattle

Enriched functions p-Value Z-score Molecules
Down group
 Immune response of leukocytes 1.14E-02 −2.2 C3, CXCL8, FCGR2B, IL1B, ISG15
 Attraction of phagocytes 7.33E-05 −2.2 C3, CXCL5, CXCL8, IL1B, VCAN
 Attraction of myeloid cells 5.73E-05 −2.2 C3, CXCL5, CXCL8, IL1B, VCAN
 Cell movement of leukocytes 4.17E-02 −2.0 C3, CXCL5, CXCL8, FOS, IL1B, S100A9, VCAN
 Infection of cells 2.35E-03 −2.0 C2, C3, EIF2AK2, FCGR2B
 Stimulation of leukocytes 1.18E-02 −2.0 C3, CXCL5, CXCL8, IL1B
 Quantity of Ca2+ 4.61E-03 −2.0 C3, CXCL8, IL1B, S100A9
 Adhesion of neutrophils 2.42E-03 −2.0 C3, CXCL8, IL1B, S100A9
 Apoptosis of macrophages 3.86E-03 −2.0 EIF2AK2, FOS, IL1B, ISG15
 Activation of granulocytes 5.11E-03 −1.9 C3, CXCL8, FCGR2B, IL1B
 Viral Infection 5.73E-05 −1.9 C2, C3, CXCL8, EGR1, EIF2AK2, FCGR2B, IL1B, MX1, S100A9
 Binding of leukocytes 1.39E-02 −1.8 A2M, C3, CXCL8, FCGR2B, IL1B, S100A9
 Fatty acid metabolism 1.78E-03 −1.8 CXCL8, CYP3A4, FABP4, FCGR2B, IL1B
 Apoptosis of leukocytes 1.14E-02 −1.8 CXCL8, EGR1, EIF2AK2, FCGR2B, FOS, IL1B, ISG15
 Cell death of immune cells 1.78E-03 −1.7 C3, CXCL8, EGR1, EIF2AK2, FABP4, FCGR2B, FOS, IL1B, ISG15, MX1, MYH11
 Degranulation of phagocytes 1.57E-04 −1.7 C3, CXCL8, DUSP1, FCGR2B, FOS, IL1B, S100A9
 Adhesion of immune cells 2.77E-02 −1.6 A2M, C3, CXCL8, IL1B, S100A9
 Binding of professional phagocytic cells 5.75E-03 −1.6 A2M, C3, CXCL8, IL1B, S100A9
 Mobilization of Ca2+ 1.14E-02 −1.6 A2M, C3, CXCL8, FCGR2B
 Migration of phagocytes 5.28E-03 −1.6 C3, CXCL5, CXCL8, IL1B, S100A9, VCAN
 Migration of granulocytes 2.35E-03 −1.5 C3, CXCL5, CXCL8, IL1B, S100A9
Up group
 Concentration of lipid 8.12E-02 −2.0 ABCA1, CXCL8, CYP1A1, CYP1B1, S100A9
 Proliferation of epithelial cells 9.40E-02 −1.8 CAV1, CDC25B, CXCL8, EDN1, FLT1, FOS, FRS2, GLI1, KRAS, KRT16, MKI67, NR3C1, ODC1, PTHLH, SULF2
 Recruitment of neutrophils 7.13E-02 −1.6 CAV1, CXCL2, CXCL5, CXCL8, CYP1A1, CYP1B1, EDN1, P2RY2
 Quantity of T lymphocytes 1.15E-01 1.5 ACKR4, BIRC5, CCNB2, CD48, FOS, IL6ST, KRAS, LGALS1, MYH11, MYSM1, NR3C1, PTTG1, TACC3, TGFBR1, TSC1, XIAP
 Differentiation of epithelial cells 7.13E-02 1.7 AURKB, CAV1, DSG1, E2F8, EDN1, GNAQ, KRAS, KRT14, KRT16, PLK1, PTHLH, SH3PXD2A
 Transmigration of myeloid cells 7.13E-02 2.0 CXCL5, CXCL8, ITGAV, LGALS1
 Transmigration of phagocytes 9.78E-02 2.0 CXCL5, CXCL8, ITGAV, LGALS1
 Cell cycle progression 7.13E-02 2.2 BIRC5, CDC25B, CKAP2, FOS, KRAS, LGALS4, MAP3K1, PLK1, XIAP