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Table 5 Enriched KEEG pathways of DE genes in the Down and Up group using DAVID (89% grain vs. 72% grain)

From: Transcriptome analysis of ruminal epithelia revealed potential regulatory mechanisms involved in host adaptation to gradual high fermentable dietary transition in beef cattle

Term p value Molecules
Down Group
Down-regulated genes (n = 45)
 bta05150: Staphylococcus aureus infection 1.5E-04 FCGR2B, C3, C2, C1QB
 bta04610: Complement and coagulation cascades 2.9E-04 A2M, C3, C2, C1QB
Up-regulated genes (n = 22)
 bta04660: T cell receptor signaling pathway 9.34E-03 CD3D, CD3G, FOS
Up Group
Down-regulated genes (n = 163)
 bta04110:Cell cycle 1.07E-05 PLK1, CCNA2, ESPL1, CDC20, PTTG1, CCNB1,
 bta00010:Glycolysis/Gluconeogenesis 2.02E-02 GAPDH, LDHB, ENO2, ENO1
 bta04068:FoxO signaling pathway 4.35E-02 PLK1, MAPK11, BNIP3, CCNB1, CCNB2
 bta04115:p53 signaling pathway 4.37E-02 GTSE1, RRM2, CCNB1, CCNB2
 bta04978:Mineral absorption 4.48E-02 SLC26A6, MT1E, MT2A
Up-regulated genes (n = 122)
 bta00380: Tryptophan metabolism 2.77E-02 AOX1, CYP1A1, CYP1B1
 bta00830:Retinol metabolism 3.00E-02 CYP1A1, ADH6, AOX1
 bta00982:Drug metabolism - cytochrome P450 3.73E-02 ADH6, AOX1, FMO5
 bta00980:Metabolism of xenobiotics by cytochrome P450 4.52E-02 CYP1A1, ADH6, CYP1B1