Fig. 1

Manhattan plot of QTL locations for lactose concentration. The X-axis shows the positions of 1.1 million variants across the 29 autosomes in the UMD 3.1 Bos taurus reference genome; the Y-axis shows the negative log of the p-values calculated for each variant. Variants illustrated using a triangle sit beyond the limit of the Y-axis. The black line shows the nominal significance threshold incorporating a Bonferroni correction for multiple hypothesis testing. The red line shows the combined inflation and multiple testing-adjusted threshold