Table 3 Reported human T-cell epitopes/HLA ligands of ZEBOV that matched the predicted epitopes
From: Mapping HLA-A2, -A3 and -B7 supertype-restricted T-cell epitopes in the ebolavirus proteome
Protein | Sequence | NetCTLpan supertype prediction | Antigen specific T-cell response |
|---|---|---|---|
HLA alleles assessed | |||
NP | IPVYQVNNL | B7 | B7: HLA-B*07:02 |
RLEELLPAV | A2 | A2: HLA-A*02:01 | |
FLSFASLFL | A2 | A2: HLA-A*02:01 | |
HPLARTAKV | B7 | B7: HLA-B*07:02, HLA-B*35:01, HLA-B*51:01 | |
GLFPQLSAI | A2 | A2: HLA-A*02:01 | |
FPQLSAIAL | B7 | A2: HLA-A*02:01 B7: HLA-B*07:02 | |
QTNAMVTLR | A3 | A3: HLA-A*03:01, HLA-A*11:01 | |
KLTEAITAA | A2 | A2: HLA-A*02:01 | |
VP40 | LPQYFTFDL | B7 | B7: HLA-B*07:02, HLA-B*35:01 |
FTFDLTALK | A3 | A3: HLA-A*03:01, HLA-A*11:01 | |
“Pre-295 All GP” | ILFQRTFSI | A2 | A2: HLA-A*02:01 A3: HLA-A*03:01, HLA-A*11:01 |
FLLQLNETI | A2 | A2: HLA-A*02:01 | |
“Post-295 GP” | MASENSSAM | B7 | A2: HLA-A*02:01 B7: HLA-B*07:02 |
LITNTIAGV | A2 | A2: HLA-A*02:01 | |
LANETTQAL | B7 | B7: HLA-B*07:02, HLA-B*35:01 | |
RTFSILNRK | A3 | A2: HLA-A*02:01 A3: HLA-A*03:01, HLA-A*11:01 | |
KAIDFLLQR | A3 | A2: HLA-A*02:01 A3: HLA-A*03:01, HLA-A*11:01 | |
VP24 | VLSDLCNFL | A2 | A2: HLA-A*02:01 |
L | IISDLSIFI | A2 | A2: HLA-A*02:01, HLA-A*69:01 |
LLADGLAKA | A2 | A2: HLA-A*02:01, HLA-A*69:01 | |
HSGFIYFGK | A3 | A3: HLA-A*11:01, HLA-A*31:01 | |
KLINTLFHA | A2 | A2: HLA-A*02:01 | |
TPVMSRFAA | B7 | B7: HLA-B*07:02, HLA-B*35:01 | |
KPTFKHASV | B7 | B7: HLA-B*07:02 |