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Table 2 Functional enrichments of putative transcriptional target genes using Pathway Commons

From: Characteristics of functional enrichment and gene expression level of human putative transcriptional target genes

Monocytes – Pathway Commons No. of TFs
 Proteoglycan syndecan-mediated signaling events 18
 Regulation of CDC42 activity 15
 LKB1 signaling events 14
 Glypican pathway 13
 Interferon Signaling 13
 Sphingosine 1-phosphate (S1P) pathway 13
 IL5-mediated signaling events 12
 Syndecan-1-mediated signaling events 12
 IL3-mediated signaling events 11
 Mitotic Prophase 11
 Golgi Cisternae Pericentriolar Stack Reorganization 11
 Interferon alpha/beta signaling 11
 IFN-gamma pathway 10
 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) 10
 Recruitment of mitotic centrosome proteins and complexes 10
CD4+ T cell – Pathway Commons No. of TFs
 TCR signaling in naive CD8+ T cells 36
 IL12-mediated signaling events 24
 Downstream signaling in naive CD8+ T cells 21
 TCR signaling in naive CD4+ T cells 21
 IL12 signaling mediated by STAT4 20
 Validated transcriptional targets of AP1 family members Fra1 and Fra2 19
 CXCR4-mediated signaling events 17
 ATF-2 transcription factor network 15
 Thrombin/protease-activated receptor (PAR) pathway 14
 TCR signaling 14
 PAR1-mediated thrombin signaling events 14
 Downstream TCR signaling 14
 Internalization of ErbB1 13
 Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling 13
 ErbB receptor signaling network 13
CD20+ B cell – Pathway Commons No. of TFs
 Interferon alpha/beta signaling 12
 Alpha6Beta4Integrin 11
 Validated targets of C-MYC transcriptional activation 11
 IL8- and CXCR2-mediated signaling events 10
 Antigen processing-Cross presentation 9
 BCR signaling pathway 9
 IL6-mediated signaling events 9
 Cell junction organization 9
 ER-Phagosome pathway 8
 Regulation of CDC42 activity 8
 CXCR4-mediated signaling events 8
 CDC42 signaling events 8
 Syndecan-4-mediated signaling events 8
 Noncanonical Wnt signaling pathway 7
 Class I MHC mediated antigen processing & presentation 7