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Table 2 Functional enrichments of putative transcriptional target genes using Pathway Commons

From: Characteristics of functional enrichment and gene expression level of human putative transcriptional target genes

Monocytes – Pathway Commons

No. of TFs

 Proteoglycan syndecan-mediated signaling events

18

 Regulation of CDC42 activity

15

 LKB1 signaling events

14

 Glypican pathway

13

 Interferon Signaling

13

 Sphingosine 1-phosphate (S1P) pathway

13

 IL5-mediated signaling events

12

 Syndecan-1-mediated signaling events

12

 IL3-mediated signaling events

11

 Mitotic Prophase

11

 Golgi Cisternae Pericentriolar Stack Reorganization

11

 Interferon alpha/beta signaling

11

 IFN-gamma pathway

10

 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

10

 Recruitment of mitotic centrosome proteins and complexes

10

CD4+ T cell – Pathway Commons

No. of TFs

 TCR signaling in naive CD8+ T cells

36

 IL12-mediated signaling events

24

 Downstream signaling in naive CD8+ T cells

21

 TCR signaling in naive CD4+ T cells

21

 IL12 signaling mediated by STAT4

20

 Validated transcriptional targets of AP1 family members Fra1 and Fra2

19

 CXCR4-mediated signaling events

17

 ATF-2 transcription factor network

15

 Thrombin/protease-activated receptor (PAR) pathway

14

 TCR signaling

14

 PAR1-mediated thrombin signaling events

14

 Downstream TCR signaling

14

 Internalization of ErbB1

13

 Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

13

 ErbB receptor signaling network

13

CD20+ B cell – Pathway Commons

No. of TFs

 Interferon alpha/beta signaling

12

 Alpha6Beta4Integrin

11

 Validated targets of C-MYC transcriptional activation

11

 IL8- and CXCR2-mediated signaling events

10

 Antigen processing-Cross presentation

9

 BCR signaling pathway

9

 IL6-mediated signaling events

9

 Cell junction organization

9

 ER-Phagosome pathway

8

 Regulation of CDC42 activity

8

 CXCR4-mediated signaling events

8

 CDC42 signaling events

8

 Syndecan-4-mediated signaling events

8

 Noncanonical Wnt signaling pathway

7

 Class I MHC mediated antigen processing & presentation

7