Fig. 3

High Variability Regions as functional regions. a HVRs and Ensembl genes (orange) across chr11 for LHvsLN (red) and for LLvsLN (green). We tested for significant enrichment of HVRs with several genetic elements using permutation tests. We compared the observed values (OV) and the expected values (EV) to determine significance. Similar analyses was done for: b Ensembl annotated rat genes (v69). c Genes whose expression differed either in liver or in kidney between LH and LN strains, and between LL and LN. d Rat orthologues of human GWAS variants associated with metabolic traits. e Occupancy in BN rat strain of three liver-specific transcription factors (CEBPA, FOXA1 and HFN4A). Related Figures: Additional file 1: Figures S4, S5 and S6