Fig. 5
Integrating results from the three liver-specific transcription factors. a Venn diagrams of HVRs with at least one conserved binding site between rats and mice (HVR subsets with CEf > 0) for the three liver-specific transcription factors. b Genes overlapping HVR subsets. The colour gradient shows the significance obtained from the enrichment analyses. Bar sizes indicates the total number of genes overlapping each subset of HVRs. c Liver-genes according to UP_TISSUE annotation. The functional annotation analyses were calculated by DAVID 6.7. Colour gradient and bar size defined as above. d Rat orthologues of human GWAS SNPs associated with obesity and metabolic traits. Colour gradient and bar size defined as above. e Ratio of genes differentially expressed in either liver or kidney between LH and LN, and between LL and LN calculated for each subset of HVRs is not influenced by the number of bound factors