Fig. 6

Network analysis based on protein-protein interactions for the human orthologues associated with the significant enrichment for obesity. Human orthologues of the 32 rat genes assigned to promoters with SSVs overlapping the selected HVRs in the LH strain and associated with obesity were analysed (black circles). Relationships among these genes were investigated using GeneMANIA (see Methods). The grey circles are genes predicted by GeneMANIA to be in the network. Of 20 significant GO Terms (q-value <0.05) total, two are presented in the figure due to their significance and the number of genes included in each module (green circles: ‘Circadian rhythm’, q-value <1e-8; red circles: ‘Negative regulation of TGF-beta receptor signalling pathway’, q-value <0.01)