Table 3 Top loci identified as transferred from adipocyte to macrophage
Location | Gene Symbol | AD GTa | MO GT | Allele Typeb | MOcoN1 | MOcoN2 | MOcoN3 | MOalone Count | FDR | ADMOexosome FPKMd | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BFc | Count | BF | Count | BF | Count | ||||||||
chr16:88,718,047 | PIEZO1 | C/C | T/T | T|C | 2.19E + 13 | 6|5 | 5.25E + 03 | 17|2 | 1.07E + 07 | 40|4 | 24 | 2.78E-06 | 2.21E-01 |
chr9:35,657,841 | RMRP | A/G | G/G | G|A|T|C|N | 1.69E + 32 | 1917|25|1|0|0 | 8.25E + 02 | 20,459|18|6|5|1 | 1.05E + 03 | 22,090|19|14|4|0 | 21,575|10|1|5|0 | 8.41E-06 | 1.89E-01 |
chr1:183,136,570 | LAMC1 | A/G | G/G | G|A | 1.97E + 02 | 82|2 | 1.03E + 07 | 92|4 | 2.06E + 01 | 141|2 | 92 | 7.65E-05 | 1.64E-01 |
chr19:7,692,417 | FCER2 | T/C | T/T | T|C | 8.00E + 00 | 29|1 | 1.34E + 02 | 26|2 | 1.36E + 03 | 40|3 | 49 | 6.12E-04 | 6.45E-01 |
chr6:75,666,836 | SENP6 | G/G | A/A | A|G|C | 6.08E + 05 | 39|4|0 | 1.42E + 01 | 171|2|0 | 2.60E + 00 | 224|2|1 | 131 | 1.57E-03 | 1.08E + 00 |
chr14:77,575,179 | SPTLC2 | T/C | T/T | T|C | 5.67E + 09 | 8|4 | NA | NA | 3.72E + 23 | 23|10 | 6 | 1.59E-03 | 5.10E-01 |
chr6:159,682,052 | SOD2 | T/C | C/C | C|T | 7.03E + 02 | 67|2 | 6.04E + 00 | 269|2 | 2.33E + 00 | 507|2 | 135 | 6.30E-03 | 1.76E + 00 |
chr4:102,344,186 | SLC39A8 | A/C | C/C | C|A | 1.67E + 04 | 17|2 | 1.16E-01 | 12 | 1.63E + 03 | 50|2 | 13 | 6.40E-03 | 1.48E + 00 |
chr20:17,607,288 | DSTN | G/G | A/A | A|G | 4.13E + 03 | 11|2 | 1.44E + 06 | 124|5 | 3.29E-02 | 297|1 | 163 | 9.72E-03 | 1.33E + 00 |
chr20:41,180,020 | ZHX3 | G/G | T/T | T|G | 5.58E + 00 | 11|1 | 1.49E + 02 | 27|2 | 5.96E-01 | 67|1 | 30 | 1.42E-02 | 5.09E-01 |
chr13:29,766,448 | UBL3 | T/C | T/T | T|C | 4.14E-01 | 60|1 | 1.74E + 00 | 135|2 | 6.74E + 00 | 104|2 | 107 | 1.90E-02 | 2.22E-01 |
chr14:75,278,923 | FOS | T/C | T/T | T|C | 9.20E-01 | 89|1 | 7.94E-01 | 398|2 | 6.82E + 00 | 542|3 | 288 | 2.68E-02 | 2.60E-01 |
chr4:119,217,669 | USP53 | A/G | A/A | A|G | 1.08E-01 | 13 | 6.08E + 01 | 41|2 | 1.42E + 02 | 42|2 | 14 | 3.28E-02 | 8.99E-02 |
chr16:68,095,198 | NFATC3 | A/A | G/G | G|A | NA | NA | 5.09E + 02 | 8|2 | 4.85E + 09 | 20|4 | 4 | 3.99E-02 | 1.39E + 00 |
chr4:48,586,725 | FRYL | C/C | T/T | T|C | 1.08E + 00 | 39|1 | 3.81E-01 | 67|1 | 4.48E + 00 | 127|2 | 53 | 4.10E-02 | 6.71E-01 |
chr11:62,524,481 | AHNAK | T/A | A/A | A|T | 2.45E + 01 | 14|1 | 2.34E + 00 | 111|1 | 2.14E-01 | 333|1 | 214 | 4.37E-02 | 2.89E-01 |
chr10:32,925,874 | ITGB1 | A/A | G/G | G|A | 8.20E-02 | 178|2 | 3.23E + 01 | 484|3 | 2.70E + 02 | 912|6 | 482|1 | 9.04E-02 | 5.15E-01 |