Table 6 Analysis of the genetic variation (Variome) of the genes that conform the two-component systems in S. pneumoniae
From: The variome of pneumococcal virulence factors and regulators
Virulence Factor Genes | Length | Mutations | Variants | Analyzed Sequences | |||||
|---|---|---|---|---|---|---|---|---|---|
Name | Locus in TIGR4 / R6 | Gene (bp) | Protein (a.a.) | Overall | Synonimous | Non-Synonimous | Allelles | Protein | |
rr14 | sp_0376 / spr0336 | 690 | 229 | 17 | 15 | 2 | 14 | 5 | 26 |
hk11 | sp_2001 / spr1815 | 1098 | 365 | 247 | 142 | 105 | 18 | 18 | 25 |
hk10 | sp_0604 / spr0529 | 1329 | 442 | 33 | 16 | 17 | 17 | 16 | 25 |
hk06 | sp_2192 / spr1997 | 1332 | 443 | 33 | 23 | 10 | 17 | 12 | 25 |
hk13 | sp_0527 / spr0464 | 1341 | 446 | 272 | 153 | 119 | 12 | 11 | 25 |
rr13 | sp_0526 / spr0463 | 738 | 245 | 78 | 65 | 13 | 11 | 11 | 25 |
rr11 | sp_2000 / spr1814 | 600 | 199 | 77 | 56 | 21 | 15 | 10 | 25 |
hk03 | sp_0386 / spr0343 | 996 | 331 | 36 | 26 | 10 | 13 | 10 | 25 |
hk01 | sp_1632 / spr1473 | 975 | 324 | 20 | 11 | 9 | 13 | 10 | 25 |
hk09 | sp_0662 / spr0579 | 1692 | 563 | 23 | 17 | 6 | 15 | 8 | 25 |
rr01 | sp_1633 / spr1474 | 678 | 225 | 13 | 10 | 3 | 13 | 8 | 25 |
rr09 | sp_0661 / spr0578 | 738 | 245 | 14 | 10 | 4 | 12 | 7 | 25 |
rr04 | sp_2082 / spr1893 | 708 | 235 | 49 | 17 | 32 | 9 | 6 | 25 |
rr03 | sp_0387 / spr0344 | 633 | 210 | 14 | 10 | 4 | 12 | 5 | 25 |
rr10 | sp_0603 / spr0528 | 657 | 218 | 15 | 10 | 5 | 11 | 5 | 25 |
rr06 | sp_2193 / spr1998 | 654 | 217 | 9 | 5 | 4 | 7 | 5 | 25 |
rr08 | sp_0083 / spr0076 | 699 | 232 | 10 | 6 | 4 | 10 | 4 | 25 |
hk04 | sp_2083 / spr1894 | 1332 | 443 | 12 | 9 | 3 | 10 | 4 | 25 |
hk08 | sp_0084 / spr0077 | 1053 | 350 | 14 | 12 | 2 | 11 | 3 | 25 |
rr05 | sp_0798 / spr0707 | 675 | 224 | 6 | 5 | 1 | 11 | 3 | 25 |
hk02 | sp_1226 / spr1106 | 1350 | 449 | 12 | 10 | 2 | 10 | 3 | 25 |
rr02 | sp_1227 / spr1107 | 705 | 234 | 7 | 7 | 0 | 11 | 2 | 25 |
hk05 | sp_0799 / spr0708 | 1335 | 444 | 11 | 10 | 1 | 9 | 2 | 25 |
hk07 | sp_0155 / spr0153 | 1647 | 548 | 68 | 46 | 22 | 19 | 17 | 24 |
rr07 | sp_0156 / spr0154 | 1287 | 428 | 50 | 33 | 17 | 17 | 14 | 24 |
rr12 | sp_2235 / spr 2041 | 753 | 250 | 11 | 8 | 3 | 10 | 3 | 24 |
hk12 | sp_2236 / spr2042 | 1326 | 441 | 42 | 16 | 26 | 11 | 9 | 23 |