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Fig. 3 | BMC Genomics

Fig. 3

From: Global accumulation of circRNAs during aging in Caenorhabditis elegans

Fig. 3

Global circRNA accumulation during aging. a Principal component analysis of circRNA Transcripts Per Million reads (TPM) shows clear clustering of young (L4, D-1) versus old ages (D-7, D-10). b Plot of circRNA TPM fold changes in aging time-point pairwise comparisons. Red line represents 1.5-fold increase and blue line represents 1.5-fold decrease. c CircRNA TPM compared among the four aging time-points: L4 larvae (L4), Day 1 (D-1), Day 7 (D-7) and Day 10 (D-10). P values reflect non-parametrical Kruskal-Wallis with Nemenyi post-hoc test for multiple comparisons. d Pairwise comparisons of age-increased and decreased circRNAs among the aging time-points (>1.5 FC, P < 0.05, FDR < 0.2). e Histogram showing number of circRNAs specifically expressed at a single time-point (6 or more reads among 3 biological replicates)

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