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Fig. 2 | BMC Genomics

Fig. 2

From: A-to-I RNA editing in the rat brain is age-dependent, region-specific and sensitive to environmental stress across generations

Fig. 2

Age-dependent changes in A-to-I RNA editing and gene expression in rat brain. a Significant age-dependent changes in RNA editing at non-synonymous editing sites in PFC (a 1 ) and AMY (a 2 ). b Age-dependent changes in Adar and Adarb1 mRNA expression in PFC (b 1 ) and AMY (b 2 ). c Age-dependent changes in Htr2c A-D site editing (c 1 ) and mRNA expression (c 2 ) in PFC. d Age-dependent changes in Htr2c A-D site editing (d 1 ) and mRNA expression (d 2 ) in AMY. e Age-dependent changes in Htr2c isoform prevalence in PFC (e 1 ) and AMY (e 2 ). Columns represent individual samples. Rows represent editing sites. *p < 0.05, **p < 0.001, # < 0.075, white, significance in PFC; gray, significance in AMY. N’s, RNA editing; P0 5, P60 5; Gene expression (Adar/b1), PFC: 12, 5; AMY: 9, 5; Htr2c, 11, 5; 5, 9

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BMC Genomics

ISSN: 1471-2164

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