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Fig. 1 | BMC Genomics

Fig. 1

From: A chelicerate-specific burst of nonclassical Dscam diversity

Fig. 1

Genome-wide identification and classification of Dscams in Chelicerata. a Schematic representation of Dscam structures in Chelicerata. Ig, immunoglobulin domains; FNIII, fibronectin III domains. The N-terminal small boxes represent the leader peptides. The lavender blue and green boxes represent the transmembrane (TM) and cytoplasmic domains. Five Dscam types (LDscam, mDscam, sDscamα, sDscamβ, and sDscamγ) are classified based on their size and structure. LDscam shares structures identical to classical Dscam. mDscam lacks Ig10 and FNIII 3–4 domains of classical Dscam. sDscamα contains variable N-terminal IgI (blue), which corresponds to the variable Ig7 domain of Drosophila Dscam1. sDscamβ contains variable N-terminal Ig1 + 2 domains (coloured), which correspond to the variable Ig7 + 8 domains of Drosophila Dscam1. Numbers in parentheses refer to the numbers of 5′ variable cassettes in Metaseiulus occidentalis sDscamα and sDscamβ2. sDscamγ shares domains similar to sDscamα and sDscamβ, albeit with no tandemly arrayed cassettes in the 5′ regions. Numbers in parentheses refer to the numbers of tandem cassettes. b Phylogenetic distribution of Dscams and isoform members in chelicerates. Dscams are shown associated with a cladogram of phylogenetic relationships in this study [52]. # Indicates the putative numbers of Dscam isoforms in various arthropod species caused by either gene and/or exon duplication, estimated by the number of Ig7 or orthologues

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