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Table 3 Top five significant networks from intolerant SNPs exclusively from the layer or broiler line

From: Genome-wide characterization of genetic variants and putative regions under selection in meat and egg-type chicken lines

Moleculesa

Total no of molecules

Score

Top diseases and functions

Layer line

 BPI, DISC1, DYX1C1, IRG1, KNTC1, MAST2, MLKL, ODF2L, TELO2, TPO

34

54

cellular morphology, assembly, organization and maintenance

 ACO1, FSH, ING1, LH, NEB, NPR2, PHKA2, RB1CC1, TNK2, Tropomyosin

27

37

organ morphology, organismal development and reproductive system development

 AFF1, BARD1, CDC2, Cyclin A, Cyclin D, Cyclin E, EFHC1, ESR1, GNPAT, RB

27

37

developmental disorder, immunological disease and cancer

 Alpha tubulin, Beta Tubulin, Dynein, EDIL3, ERK, FBN1, GPSM2, Growth Factor Receptor, INCENP, NPHP1

26

35

cellular assembly, organization, function, maintenance and cycle

 ADCY, Caveolin, FHL5, GLUD1, IDH2, INSR, Insulin, LEPR, Proinsulin, Trypsin

24

31

reproductive system development, cellular growth and proliferation and endocrine system disorders

Broiler line

 AMY2A, Amylase, Apyrase, DMBT1, EDA2R, NGNL2, INF2, NKRF, NUAK2, OTULIN

32

41

lipid metabolism, nervous system development and post-translational modification

 AMOTL2, ERK, FBF1, IQCE, MIPOL1, SCEL, SETD5, SH3RF2, SMPD1, TIPIN

32

41

carbohydrate and drug metabolism and small molecule biochemistry

 AKAP, AKAP6, AKAP9, DISC1, LXN, MAPRE3, PCNXL4, PPM1E, RPS6KA1, SCT

32

41

cellular morphology, assembly, organization, function and maintenance

 DCHS1, DHX30, EFCAB11, ESR, FTSJ3, HEATR1, MGA, MRPL3, NDC1, UTRN

31

38

metabolic disease, hereditary disorder and cell cycle

 Aconitase, CRISP2, LAMA1, MEF2, MYBPH, MYH2, MYO9A, NFS1, OFD1, Tubulin

30

37

cancer, dermatological diseases, organismal injury and abnormalities

  1. aExample of ten molecules present in each network