Table 2 Ten most significant differentially methylated regions associated with migraine
Chromosome | Start (bp) | End (bp) | Direction | P value | FDR | No. of Probes | RefSeq gene(s) |
|---|---|---|---|---|---|---|---|
11 | 20,625,538 | 20,628,781 | Decrease | 2.54 × 10− 17 | 4.16 × 10− 12 | 10 | SLC6A5 |
6 | 30,033,321 | 30,046,936 | Decrease | 1.50 × 10− 14 | 1.23 × 10− 9 | 128 | PPP1R11, RNF39 |
9 | 124,987,896 | 124,992,432 | Increase | 1.65 × 10− 12 | 8.99 × 10−8 | 13 | LHX6 |
3 | 185,911,208 | 185,913,486 | Decrease | 5.28 × 10−12 | 2.16 × 10−7 | 9 | DGKG |
13 | 31,506,270 | 31,508,139 | Decrease | 2.15 × 10−11 | 7.04 × 10−7 | 11 | TEX26, TEX26-AS1 |
11 | 67,417,958 | 67,419,405 | Decrease | 6.54 × 10−10 | 1.79 × 10− 5 | 13 | ACY3 |
5 | 156,886,147 | 156,888,490 | Decrease | 1.26 × 10−9 | 2.95 × 10− 5 | 12 | LOC102724404, NIPAL4 |
6 | 74,070,966 | 74,075,136 | Increase | 1.99 × 10−9 | 4.08 × 10− 5 | 16 | KHDC3L |
12 | 52,403,511 | 52,405,422 | Decrease | 2.65 × 10−9 | 4.34 × 10− 5 | 6 | GRASP |
13 | 31,479,366 | 31,482,184 | Decrease | 2.46 × 10−9 | 4.34 × 10−5 | 13 | MEDAG, TEX26-AS1 |