Table 1 Mutations of the influenza TW17 compared to the SH13 strain
From: Computational analysis of the receptor binding specificity of novel influenza A/H7N9 viruses
Impact | Protein | Mutations |
|---|---|---|
Viral oligomerization interfaces or binding small ligands | HA | I56T, A130P, S136N, I138T, A143V, K182E, L235Q, M245I, A310T, I335V, G338A, E396A, E403K, S499R |
M2 | E24D | |
NA | M26I, M72I, Y166H, A210V, S242P, R289K, N322S | |
PA | G66S | |
aPB2 | M570I, E627K | |
Host receptor binding | HA | L235Q, E396A |
Host specificity shift | PB2 | I292V, E627K |
Glycosylation | HA | S136Â N, I138T |
Antibody recognition sites | HA | I56T, A130P, S136Â N, I138T, A143V, L235Q, I335V, E396A, S499R |
| Â | NA | S242P |
Drug binding | NA | S242P, R289K |