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Fig. 1 | BMC Genomics

Fig. 1

From: VAReporter: variant reporter for cancer research of massive parallel sequencing

Fig. 1

Framework of VAReporter. VAReporter takes genetic variants from gene panel or whole-exome sequencing as input materials, supporting heterogeneous VCF formats such as GATK, VarScan, MuTect and VarDict. A wide variety of biomedical databases were compiled as local annotation resources to facilitate the interpretation of biological effects introduced by genetic alterations. MutSigCV algorithm was also incorporated into the framework to detect significantly altered genes in study cohorts. Visualization modules are widely used for displaying sample-wide mutation profiles, landscapes, spectra and affected pathways. Dynamic tables with filtering and sorting functionalities are provided to facilitate the prioritization of clinically actionable targets

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