Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia

Huang, Xiao; Anderle, Pascale; Hostettler, Lu; Baumann, Marc U.; Surbek, Daniel V.; Ontsouka, Edgar C.; Albrecht, Christiane

doi:10.1186/s12864-018-4518-z

Table 2 Selected nutrient transporters according to their regulational signature and physiological significance

From: Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia

Substrate class	Predominant (predicted) substrate	Gene name	Accession number	Protein name	Log (FC)	Representative references
Amino acids	System L, y⁺L, xc-and asc [58, 59]	SLC3A2	NM002394	4F2hc	− 0.42~ 0.28	[60,61,62,63]
	Cationic L- amino acids	SLC7A1	NM003045	CAT1	− 0.52~ 0.89	[64,65,66,67]
	Large neutral L-amino acids	SLC7A5	NM003486	LAT1	−0.38~ 0.46	[62, 63, 66, 68,69,70,71]
	Cationic amino acids, large neutral L-amino acids	SLC7A6	NM003983	y⁺LAT2	−0.23~ 0.39	[69, 72]
	Cationic amino acids, large neutral L-amino acids	SLC7A7	NM001126105	y⁺LAT1	− 0.44~ 0.89	[72]
	Neutral L – amino acids	SLC7A8	NM012244	LAT2	−0.12~ 0.25	[73]
	Cystine (anionic form), L-glutamate	SLC7A11	NM014331	xCT	−0.10~ 0.53	–
	Gln, Ala, Asn, Cys, His, Ser	SLC38A1	NM030674	SNAT1	−0.28~ 1.24	[68, 74, 75]
	Ala, Asn, Cys, Gln, Gly, His, Met, Pro, Ser	SLC38A2	NM018976	SNAT2	− 0.11~ 0.11	[50, 68, 75,76,77,78]
	Gln, Asn, His, Ser	SLC38A5	NM033518	SNAT5	0.01~ 0.21	[49]
	Polyamines, amino acids [79]	SLC12A8	NM024628	CCC9	−0.45~ 1.09	–
Vitamins	Thiamine [27]	SLC19A2	NM006996	THTR1	0.28~ 0.66	[80]
	Thiamine [27]	SLC19A3	NM025243	THTR2	−1.17~ − 0.12	[80, 81]
	Folate	SLC19A1	NM194255	RFC	−0.10~ 0.84	[82,83,84,85]
	Folate	SLC46A1	NM080669	PCFT	− 0.15~ 0.05	[82, 86]
	Biotin, pantothenic acid [87]	SLC5A6	NM021095	SMVT	0.01~ 0.04	[88, 89]
	Cobalamin [90]	LMBRD1	NM018368	LMBRD1	−0.26~ 0.22	–
	(Pyridoxine) [91]	SLC22A15	NM018420	FLIPT1	−0.14~ 0.10	–
	L-ascorbic acid [92, 93]	SLC23A1	NM005847	SVCT1	0.01~ 0.10	[94, 95]
		SLC23A2	NM005116	SVCT2	−0.38~ 0.43	[95,96,97]
		SLC23A3	NM144712	SVCT3	− 0.21~ 0.33	–
Microelements and ions	Zn²⁺ [98, 99]	SLC30A1	NM021194	ZNT1	−0.02~ 0.34	[100,101,102]
		SLC30A2	NM032513	ZNT2	− 0.06~ 0.17	[100, 101, 103]
		SLC30A4	NM013309	ZNT4	−0.21~ 0.05	[100, 101]
		SLC39A1	NM014437	ZIP1	− 0.13~ 0.04	[100]
		SLC39A8	NM022154	ZIP8	0.00~ 0.95	[104]
	Ca²⁺	TRPV6	NM018646	TRPV6	0.02~ 0.43	[32, 105,106,107]
	e.g. Cl⁻,(COO)₂²⁻ [108]	SLC4A1	NM000342	AE1	−0.48~ 0.53	[109, 110]
	e.g. SO₄²⁻ [111]	SLC26A2	NM000112	DTDST	−0.78~ 0.74	[43, 112]
	e.g. SO₄²⁻ [111]	SLC26A6	NM134426	Pat-1	− 0.09~ 0.47	[112]
	e.g. Na⁺, H⁺ [113, 114]	SLC9A1	NM003047	NHE1	−0.34-0.00	[110, 115,116,117]
	e.g. Na⁺, H⁺ [113, 114]	SLC9B2	NM178833	NHA2	− 0.35~ − 0.34	–
	e.g. I⁻ [111, 118]	SLC5A5	NM000453	NIS	−0.12~ 0.08	[119,120,121,122]
	e.g. I⁻ [111, 118]	SLC26A4	NM000441	PDS	0.00~ 0.04	[121, 123, 124]
	e.g. Fe²⁺, Zn²⁺ [125]	SLC11A2	NM000617	DMT1	−0.07~ 0.67	[126,127,128]
Lipids	Cholesterol, phospholipids [129]	ABCA1	NM005502	ABCA1	−0.19~ 0.71	[21, 130, 132]
	Cholesterol, phospholipids [129]	ABCG1	NM207629	ABCG1	− 0.20~ 0.33	[130, 131]
	Drugs, toxins [133]	ABCG2	NM004827	ABCG2	−0.70~ 0.48	[134,135,136]
	e.g. flavonoids [137]	SLC47A1	NM018242	MATE1	−0.03~ 0.33	[138, 139]
	LCFA, VLCFA [140]	SLC27A2	NM003645	FATP2	−0.58~ 1.37	[141, 142]
	LCFA, VLCFA [140]	SLC27A4	NM005094	FATP4	− 0.04~ 0.05	[142,143,144]
Carbohydrates (+ metabolic derivatives)	Glucose [145]	SLC2A1	NM006156	GLUT1	0.12~ 0.66	[20, 40, 146]
	Lactate [147]	SLC16A1	NM003051	MCT1	−0.36~ 1.35	[148,149,150]
		SLC16A3	NM004207	MCT4	− 0.12~ 0.48	[148,149,150,151]
		SLC16A4	NM004696	MCT5	− 0.50~ 0.47	[149]
Neurotransmitter	Norepinephrine [152]	SLC6A2	NM001043	NET	−0.31~ 0.54	[153,154,155]

Forty six entries were ordered alphabetically by gene name; pivotal information of targets including a representative example of accession number, and protein name, substrate (class), and Log (FC) value from meta-analysis is listed
Abbreviations: SLC solute carrier, LCFA long chain fatty acid, VLCFA very long chain fatty acid

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