Fig. 2

Identification of genes with holistic effects on yeast morphology. a Distribution of Euclidian distances (Additional file 2: Table S1). Blue, gray, and yellow boxes indicate non-essential gene deletion mutants with significant holistic morphological abnormality (left axis), other deletion mutants (left axis), and 109 replicates of the wild type (right axis), respectively, in 57-dimensional orthogonal space. The vertical solid red line indicates false discovery rate (FDR) = 0.01, and the purple curved line indicates a gamma distribution fitted to the wild-type replicates. b Scatter plot of non-essential gene deletion mutants in terms of holistic morphological abnormality (x-axis) and specific morphological abnormality (y-axis). The specific effect (y-axis) was defined as the maximum negative value of log-transformed p values for each of the 501 traits (Additional file 2: Table S1). Horizontal and vertical solid red lines indicate FDR = 0.01. Blue, green, orange, and black circles indicate 1126 holistic morphological mutants, 2241 specific morphological mutants, 109 replicates of the wild type, and 1351 other mutants, respectively