Fig. 1

Structural variability exists in unstructured RNA probes and correlates with protein RNA-binding. a) Distribution of standard deviation of average 5-mer base-pairing probabilities. While in random probes there is more variability, unstructured probes are still quite variable. b) Correlation of probes containing UUUUU HuR-binding intensities and UUUUU’s average base-pairing probabilities. The negative correlation shows that HuR prefers to bind unpaired regions