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Fig. 3 | BMC Genomics

Fig. 3

From: The deregulated microRNAome contributes to the cellular response to aneuploidy

Fig. 3

microRNAome of aneuploid cells affects cellular development, growth and proliferation. a Top ten cellular and molecular functions affected by the deregulated microRNAs in individual aneuploid cell lines (in alphabetical order bottom-to-top). The dot size and colour outlines the individual data and indicates the number of microRNAs that are associated with a specific cellular function. b Subfunctional annotation terms for the four cellular and molecular functions with the most miRNAs involved (columns). Each graph row contains subfunctional terms for one aneuploid cell line. The size of the boxes indicate the number of microRNAs associated (y-axis); the colour indicates the predicted activation z-score. Asterisks indicate cell lines with H2B-GFP. Hep. cells abbreviates hepatoma cell lines. c Immunoblotting of negative cell cycle regulators p21 and p27 upon transfection with inhibitors and mimics of miRNA139-5p. Left: Example of the immunoblotting, Ponceau S staining was used as a loading control. Right: Quantification based on four independent experiments, mean and standard deviation are shown

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