Fig. 7

Hepatic gene interaction networks involved in phosphorylation or retinal metabolism of riboflavin-deficient and riboflavin-rescued embryos. Panel a shows the interaction of several phosphatases and phosphorylases, including glycogen phosphorylase (PYGL) and annotated by IPA as “Carbohydrate Metabolism” and “Post-Translational Modification”. This gene network was identified in the combined dataset of all AR-DE genes found at e13 and e15. The second gene network (b), found in liver of e15 embryos was composed mainly of acyl-CoA and aldehyde dehydrogenases, and functionally annotated by IPA as involved in “Lipid Metabolism” and “Small Molecule Biochemistry”