Table 2 IPA summary of microarray analysis of liver in riboflavin-deficient chick embryos at e13
Top Canonical Pathways | p-value | Overlap | Ratio |
IL-8 Signaling | 3.85E-05 | 5.1% | 10/197 |
JAK/Stat Signaling | 2.14E-04 | 7.2% | 6/83 |
EIF2 Signaling | 4.85E-04 | 4.1% | 9/221 |
RANK Signaling in Osteoclasts | 6.17E-04 | 5.9% | 6/101 |
Proline Biosynthesis I | 6.22E-04 | 50.0% | 2/4 |
Top Upstream Regulators | p-value of overlap | # Target genes | |
E2F1 | 3.40E-07 | 19 | |
MYC | 5.14E-07 | 30 | |
ATF4 | 1.60E-06 | 10 | |
TCF3 | 4.20E-06 | 12 | |
PPARA | 9.09E-06 | 16 | |
Top Molecular and Cellular Functions | p-value | # Genes | |
Amino Acid Metabolism | 1.03E-02 - 1.07E-07 | 22 | |
Small Molecule Biochemistry | 1.03E-02 - 1.07E-07 | 58 | |
Molecular Transport | 1.03E-02 - 5.02E-06 | 59 | |
Cell Cycle | 1.03E-02 - 8.67E-06 | 38 | |
Cell Death and Survival | 1.03E-02 - 5.35E-05 | 68 | |
Physiological System Development and Function | p-value | # Genes | |
Endocrine System Development and Function | 1.03E-02 - 5.02E-06 | 7 | |
Organismal Development | 1.03E-02 - 9.26E-06 | 64 | |
Cardiovascular System Development and Function | 8.81E-03 - 1.41E-05 | 31 | |
Organ Morphology | 1.03E-02 - 1.41E-05 | 40 | |
Digestive System Development and Function | 9.14E-03 - 1.74E-05 | 34 | |
Hepatotoxicity | p-value | # Genes | |
Liver Proliferation | 2.04E-02 - 8.34E-05 | 10 | |
Liver Steatosis | 4.45E-01 - 1.55E-03 | 11 | |
Liver Fibrosis | 3.91E-01 - 1.72E-03 | 9 | |
Hepatocellular Carcinoma | 2.28E-01 - 2.89E-03 | 19 | |
Liver Hyperplasia/Hyper-proliferation | 2.43E-01 - 2.89E-03 | 76 | |
Top Up-regulated genes | log2 Rf+/Rf- | Top Down-regulated genes | log2 Rf+/Rf- |
CHODL | 1.41 | ANKRD22 | −2.74 |
FAM84A | 1.27 | OVCH2 | −2.42 |
PROZ | 1.24 | EIF5B | −2.01 |
TOP1 | 1.21 | ALDH18A1 | −1.99 |
COMT | 1.18 | CA2 | −1.97 |
F9 | 1.17 | LGALS1 | −1.77 |
RUFY2 | 1.17 | RBP7 | −1.75 |
GATM | 1.14 | PYCR2 | −1.68 |
F2 | 1.09 | PLIN2 | −1.67 |
GC | 1.07 | ASNS | − 1.38 |