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Fig. 1 | BMC Genomics

Fig. 1

From: A circulating microRNA signature as noninvasive diagnostic and prognostic biomarkers for nonalcoholic steatohepatitis

Fig. 1

Circulating microRNA expression pattern in mice fed on 3H diet for varying time points compared with chow diet control mice. a Hierarchical clustering analysis revealed differential expression pattern between chow and 3H diet fed mice in circulating microRNA profile. The distance between features/samples were calculated by Euclidean method, and clustered using the Ward algorithm. b Random forest analysis on the microRNA expression data demonstrated a greater out-of-bag error in mice fed 3H diet for 2 and 4 months, suggesting heterogeneity in disease progression. Total number of trees were 500, and number of predictors were 7. Abbreviations: 3H, high fat, high fructose and high cholesterol; 3H_2m, 3H_4m, 3H_7m, mice on 3H diet for 2 months, 4 months, and 7 months respectively; lean, mice on standard chow diet; class. Error, classification error

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