Fig. 1From: A circulating microRNA signature as noninvasive diagnostic and prognostic biomarkers for nonalcoholic steatohepatitisCirculating microRNA expression pattern in mice fed on 3H diet for varying time points compared with chow diet control mice. a Hierarchical clustering analysis revealed differential expression pattern between chow and 3H diet fed mice in circulating microRNA profile. The distance between features/samples were calculated by Euclidean method, and clustered using the Ward algorithm. b Random forest analysis on the microRNA expression data demonstrated a greater out-of-bag error in mice fed 3H diet for 2 and 4Â months, suggesting heterogeneity in disease progression. Total number of trees were 500, and number of predictors were 7. Abbreviations: 3H, high fat, high fructose and high cholesterol; 3H_2m, 3H_4m, 3H_7m, mice on 3H diet for 2Â months, 4Â months, and 7Â months respectively; lean, mice on standard chow diet; class. Error, classification errorBack to article page