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Fig. 4 | BMC Genomics

Fig. 4

From: A circulating microRNA signature as noninvasive diagnostic and prognostic biomarkers for nonalcoholic steatohepatitis

Fig. 4

The diagnostic performance of microRNA signature in discriminating mice having NAS > 3 was improved by incorporating ALT. a, b Univariate ROC analysis of miR-192 and miR-505, which was created by plotting the true positive rate (sensitivity) against false positive rate (1-specificity). The right panel depicted the expression level of miR-192 and miR-505 in mice having NAS > 3 compared with mice having NAS ≤ 3. c ROC curves of the microRNA signature in predicting mice having NAS > 3 (AUC = 0.897, 95% confidence interval: 0.75 - 1) in study 1. The confusion matrix was depicted in the inset (numbers in rows are actual classification, numbers in columns are predicted classification). d ROC curves of the microRNA signature plus ALT in predicting mice having NAS > 3 (AUC = 0.913, 95% confidence interval: 0.75 - 1) in study 1. The confusion matrix was depicted in the inset. Abbreviations: NAS, NAFLD activity score; ROC, receiver operating characteristics; AUC, area under curve

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