Table 2 Summary of major pathways over-represented in each song nucleus

 Cardiac conduction

Cardiac conduction

Cardiac conduction

Cardiac conduction

 Voltage gated K+ channels

Voltage gated K+ channels

Voltage gated K+ channels

Phase 0 - rapid depolarization

 2 pore K+ channels

Inactivation of Na + channels

Phase 2 - plateau phase

Resting membrane potential

 GPCR Adenosine A2A receptor

GPCR signaling-G alpha q

GPCR signaling-cholera toxin

G alpha (i) signaling events

 GPCR Dopamine D1 receptor

GPCRs, Class A Rhodopsin

GPCR signaling-G alpha i

GPCR signaling-G alpha q

GPCR signaling - Epac and ERK

GPCR signaling - PKA and ERK

GPCR signaling-pertussis toxin

Secretin family receptors

 Cholinergic synapse

Biogenic Amine Synthesis

Amphetamine addiction

Adrenergic signaling

Cholinergic synapse

Dopamine Release Cycle

Dopaminergic synapse

Serotonin signaling

Serotonin and anxiety

Beta-agonist/Beta-blockers

 Phospholipase D signaling

cAMP signaling pathway

Phospholipase D signaling

cGMP-PKG signaling pathway

 CREB phos. Via CaMKII

cGMP effects

PLC beta mediated events

rho-GEF activation

 Ras signaling pathway

PLC-gamma1 signaling

DAG and IP3 signaling

cGMP-PKG signaling

 HDL-mediated lipid transport

Glycerolipid metabolism

Glycosphingolipid biosynthesis

 Lysosphingolipid receptors

Phospholipid Biosynthesis

Lysosphingolipid receptors

 triacylglycerol biosynthesis

lipoprotein lipase deficiency

Glycerol Kinase Deficiency

 NGF signalling via TRKA

FGFR1 ligand binding

Signaling by EGFR

 Signaling by EGFR

FGFR2c ligand binding

Signaling by VEGF

 Signaling by PDGF

Internalization of ErbB1

 Signalling by NGF

 VEGF Signaling Pathway

 VEGFR2 mediated prolif.

 Axon guidance

Axon guidance

Axon guidance

 neurexin/neuroligin complex

neurexin/neuroligin complex

Adherens junctions interact.

 ECM-receptor interaction

Reelin signalling pathway

NCAM1 interactions

 Integrin

Netrin-1 signaling

 LGI-ADAM interactions

Cell adhesion molecules

 neurite out-growth (NCAM)

CRMPs in Sema3A signaling

 Activation of NMDA receptors

Activation of NMDA receptors

Glutamatergic synapse

Trafficking of AMPA receptors

 Calcium signaling pathway

Calcium signaling pathway

Calcium signaling pathway

 CAM-kinase activation

CAM-kinase activation

Reduction of cytosolic Ca2+

Calmodulin induced events

Sodium/Calcium exchangers

Elevation of cytosolic Ca2+

 Gastrin-CREB signaling

Gastrin-CREB signaling

Peptide binding receptors

 Oxytocin signaling pathway

Oxytocin signaling pathway

NFAT signaling in lymphocytes

 Renin secretion

Opioid Signalling

Morphine addiction

Vasopressin regulation

Morphine addiction

 Hemostasis

Hemostasis

Hemostasis

 Circadian entrainment

Circadian entrainment

Circadian entrainment

 Keratan sulfate biosynthesis

Keratan sulfate biosynthesis

 Rhodopsin-like receptors

Rhodopsin-like receptors

 Gap junction

Gap junction

 nitric oxide signaling

nitric oxide signaling pathway

 Insulin secretion

Insulin secretion

 Long-term potentiation

Long-term potentiation

 Taste transduction

Taste transduction

Aldosterone secretion

Aldosterone secretion

Purine/Pyrimidine metabolism

Purine/Pyrimidine metabolism

Olfactory transduction

Olfactory transduction

 Amyotrophic lateral sclerosis

Cell cycle: g2/m checkpoint

Aquaporin-mediated transport

Gene reg. by peroxisome proliferators

 Angiogenesis overview

Amino acid metabolism

CLEC7A/NFAT activation

 Chemokine/DAP12 signaling

somitogenesis

NDK phosphins and dynamin

 Glycosaminoglycan metabolism

Glial Cell Differentiation

FTO Obesity Mechanism

 RET signaling

peroxisomal oxidation

MNGIE disease

 Toxicity of botox A

Nicotin-ate/−amide metabolism

Regulation of pgc-1a

endocannabinoid signaling

Salivary secretion

Signaling by Wnt