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Table 3 Top significant pathways overrepresented among target genes of differentially expressed miRNAs in response to exposure of bovine macrophages in vitro to Streptococcus agalactiae strains ST103 or ST12

From: MicroRNA expression profiles of bovine monocyte-derived macrophages infected in vitro with two strains of Streptococcus agalactiae

   Pathway name P-value P-value (B-H) Genes
ST103 miRNAs up-regulated Mucin type O-Glycan biosynthesis 1.4E-4 0.01 GALNT3; GALNT4; GALNT9; POC1B-GALNT4;
GABA receptor activation 1.0E-4 0.02 GABRA1; GABRB2; GNG10; GNG5; KCNJ2;
Regulation of gene expression in early pancreatic precursor cells 0.001 0.06 ONECUT1; ONECUT3;
miRNAs down-regulated Integrin signaling pathway 0.004 0.10 ACTN1; ACTN2; BCR; CAV1; FYN; ITGA1; MAPK8; PXN; SOS1; TNS1; VCL;
Sodium/Calcium exchangers 0.003 0.11 SLC24A1; SLC24A2; SLC24A3; SLC24A4; SLC8A1; SLC8A2; SLC8A3;
Reduction of cytosolic Ca++ levels 0.004 0.11 ATP2A2; ATP2B1; ATP2B2; ATP2B3; ATP2B4; SLC8A1; SLC8A2; SLC8A3;
ST12 miRNAs up-regulated Activation of G protein gated Potassium channels 2.3E-4 0.04 GNB3; GNG10; GNG2; GNG5; KCNJ6;
G protein gated Potassium channels 2.3E-4 0.04 GNB3; GNG10; GNG2; GNG5; KCNJ6;
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 2.3E-4 0.04 GNB3; GNG10; GNG2; GNG5; KCNJ6;
miRNAs down-regulated IL4-mediated signaling events 5.1E-4 0.15 BCL2L1; CCL11; CCL26; FCER2; IL10; IRF4; IRS2; SOCS1; SOCS5; STAT6;
Intrinsic Pathway for Apoptosis 3.6E-4 0.16 BAK1; BAX; BCL2L1; BMF; CASP7; TFDP1; YWHAB; YWHAG;
Role of parkin in ubiquitin-proteasomal pathway 3.1E-4 0.28 PARK2; UBE2E2; UBE2G1; UBE2L3;
  1. GALNT3/4/9 - polypeptide N-acetylgalactosaminyltransferase 3/4/9; POC1B - POC1 centriolar protein B; GABRA1/B2 - gamma-aminobutyric acid type A receptor alpha1 subunit/beta2 subunit; GNG 2/5/10 - G protein subunit gamma 10/5; KCNJ2/6 - potassium voltage-gated channel subfamily J member 2/6; ONECUT1/3 - one cut homeobox 1/3; ACTN1/2: actinin alpha 1/2; BCR - RhoGEF and GTPase activating protein; CAV1 - caveolin 1; FYN - FYN proto-oncogene, Src family tyrosine kinase; ITGA1 - integrin subunit alpha 1; MAPK8 - mitogen-activated protein kinase 8; PXN - paxillin; SOS1 - SOS Ras/Rac guanine nucleotide exchange factor 1; TNS1 - tensin 1; VCL - vinculin; SLC24A1/2/3/4 - solute carrier family 24 member 1/2/3/4; SLC8A1/2/3 - solute carrier family 8 member 1/2/3; ATP2A2 - ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2; ATP2B1/2/3/4 -ATPase plasma membrane Ca2+ transporting 1/2/3/4; GNB3 - G protein subunit beta 3; BCL2L1- BCL2 like 1; CCL11/26 - chemokine (C-C motif) ligand 11/26; FCER2 - Fc fragment of IgE receptor II; IL10 - interleukin 10; IRF4 - interferon regulatory factor 4; IRD2 - insulin receptor substrate 2; SOCS1/5 - suppressor of cytokine signaling 1; STAT6 - signal transducer and activator of transcription 6; BAK1 - BCL-2 antagonist killer 1; BAX - BCL-2 associated X; BMF - Bcl2 modifying factor; CASP7 - caspase 7; TFDP1 - transcription factor Dp-1; YWHAB/G - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta/gamma; PARK2 - parkin RBR E3 ubiquitin protein ligase; UBE2E2/G1/L3 - ubiquitin-conjugating enzyme E2E2/E2G1/E2L3