Table 2 Significantly enriched KEGG pathways in CGS under interspecies and natural pathogen infection
RGV-1d | ADRV-1d | RGV-7d | ADRV-7d | ||||
|---|---|---|---|---|---|---|---|
KEGG | p-values | KEGG | P-values | KEGG | P-values | KEGG | P-values |
TNF signaling pathway | 6.76E-05 | Cytokine-cytokine receptor interaction | 3.02E-08 | Hematopoietic cell lineage | 0.006444 | Cytokine-cytokine receptor interaction | 1.78E-09 |
Cytokine-cytokine receptor interaction | 0.000262 | Malaria | 6.89E-05 | Cytokine-cytokine receptor interaction | 0.006444 | Hematopoietic cell lineage | 6.46E-07 |
Malaria | 0.001122 | Hematopoietic cell lineage | 0.000204 | Antigen processing and presentation | 0.006444 | NF-kappa B signaling pathway | 5.46E-05 |
Rheumatoid arthritis | 0.002056 | Transcriptional misregulation in cancer | 0.000258 | Cell adhesion molecules | 0.006444 | Malaria | 0.000397 |
Hematopoietic cell lineage | 0.002056 | Jak-STAT signaling pathway | 0.000330 | Primary immunodeficiency | 0.006444 | Rheumatoid arthritis | 0.001960 |
Jak-STAT signaling pathway | 0.003073 | TNF signaling pathway | 0.000506 | Natural killer cell mediated cytotoxicity | 0.008181 | Jak-STAT signaling pathway | 0.004337 |
Transcriptional misregulation in cancer | 0.020116 | Antigen processi and presentation | 0.000970 | Graft-versus-host disease | 0.020223 | AGE-RAGE signaling pathway in diabetic complications | 0.007612 |
Legionellosis | 0.021996 | Rheumatoid arthritis | 0.001018 | Glutathione metabolism | 0.036874 | Complement and coagulation cascades | 0.008071 |
Adipocytokine signaling pathway | 0.029942 | AGE-RAGE signaling pathway in diabetic complications | 0.004286 | Natural killer cell mediated cytotoxicity | 0.013214 | ||
Osteoclast differentiation | 0.029942 | African trypanosomiasis | 0.016042 | Measles | 0.019046 | ||
NF-kappa B signaling pathway | 0.030993 | Toll-like receptor signaling pathway | 0.025041 | Cell adhesion molecules | 0.020083 | ||
Toll-like receptor signaling pathway | 0.030993 | Legionellosis | 0.025041 | Transcriptional misregulation in cancer | 0.022477 | ||
AGE-RAGE signaling pathway in diabetic complications | 0.030993 | Leishmaniasis | 0.026544 | Leishmaniasis | 0.022477 | ||
Herpes simplex infection | 0.036416 | Hepatitis C | 0.022477 | ||||
Complement and coagulation cascades | 0.038546 | Intestinal immune network for IgA production | 0.022477 | ||||
RIG-I-like receptor signaling pathway | 0.026331 | ||||||
Allograft rejection | 0.033481 | ||||||
Staphylococcus aureus infection | 0.038645 | ||||||
Toll-like receptor signaling pathway | 0.046413 | ||||||
Epithelial cell signaling in Helicobacter pylori infection | 0.047717 | ||||||