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Table 2 Significantly enriched KEGG pathways in CGS under interspecies and natural pathogen infection

From: Divergent transcriptomic responses underlying the ranaviruses-amphibian interaction processes on interspecies infection of Chinese giant salamander

RGV-1d ADRV-1d RGV-7d ADRV-7d
KEGG p-values KEGG P-values KEGG P-values KEGG P-values
TNF signaling pathway 6.76E-05 Cytokine-cytokine receptor interaction 3.02E-08 Hematopoietic cell lineage 0.006444 Cytokine-cytokine receptor interaction 1.78E-09
Cytokine-cytokine receptor interaction 0.000262 Malaria 6.89E-05 Cytokine-cytokine receptor interaction 0.006444 Hematopoietic cell lineage 6.46E-07
Malaria 0.001122 Hematopoietic cell lineage 0.000204 Antigen processing and presentation 0.006444 NF-kappa B signaling pathway 5.46E-05
Rheumatoid arthritis 0.002056 Transcriptional misregulation in cancer 0.000258 Cell adhesion molecules 0.006444 Malaria 0.000397
Hematopoietic cell lineage 0.002056 Jak-STAT signaling pathway 0.000330 Primary immunodeficiency 0.006444 Rheumatoid arthritis 0.001960
Jak-STAT signaling pathway 0.003073 TNF signaling pathway 0.000506 Natural killer cell mediated cytotoxicity 0.008181 Jak-STAT signaling pathway 0.004337
Transcriptional misregulation in cancer 0.020116 Antigen processi and presentation 0.000970 Graft-versus-host disease 0.020223 AGE-RAGE signaling pathway in diabetic complications 0.007612
Legionellosis 0.021996 Rheumatoid arthritis 0.001018 Glutathione metabolism 0.036874 Complement and coagulation cascades 0.008071
Adipocytokine signaling pathway 0.029942 AGE-RAGE signaling pathway in diabetic complications 0.004286    Natural killer cell mediated cytotoxicity 0.013214
Osteoclast differentiation 0.029942 African trypanosomiasis 0.016042    Measles 0.019046
NF-kappa B signaling pathway 0.030993 Toll-like receptor signaling pathway 0.025041    Cell adhesion molecules 0.020083
Toll-like receptor signaling pathway 0.030993 Legionellosis 0.025041    Transcriptional misregulation in cancer 0.022477
AGE-RAGE signaling pathway in diabetic complications 0.030993 Leishmaniasis 0.026544    Leishmaniasis 0.022477
   Herpes simplex infection 0.036416    Hepatitis C 0.022477
   Complement and coagulation cascades 0.038546    Intestinal immune network for IgA production 0.022477
       RIG-I-like receptor signaling pathway 0.026331
       Allograft rejection 0.033481
       Staphylococcus aureus infection 0.038645
       Toll-like receptor signaling pathway 0.046413
       Epithelial cell signaling in Helicobacter pylori infection 0.047717
  1. Only 8 KEGG pathways were significantly enriched in RGV-7d. The same KEGG pathways between two groups at the same time points were indicated with bold font