TY - JOUR AU - Palumbo, Domenico AU - Affinito, Ornella AU - Monticelli, Antonella AU - Cocozza, Sergio PY - 2018 DA - 2018/04/02 TI - DNA Methylation variability among individuals is related to CpGs cluster density and evolutionary signatures JO - BMC Genomics SP - 229 VL - 19 IS - 1 AB - In recent years, epigenetics has gained a central role in the understanding of the process of natural selection. It is now clear how environmental impacts on the methylome could promote methylation variability with direct effects on disease etiology as well as phenotypic and genotypic variations in evolutionary processes. To identify possible factors influencing inter-individual methylation variability, we studied methylation values standard deviation of 166 healthy individuals searching for possible associations with genomic features and evolutionary signatures. SN - 1471-2164 UR - https://doi.org/10.1186/s12864-018-4618-9 DO - 10.1186/s12864-018-4618-9 ID - Palumbo2018 ER -