Gene co-expression networks in liver and muscle transcriptome reveal sex-specific gene expression in lambs fed with a mix of essential oils

Table 3 Statistically significant GSEA summary results in liver of males and females (FDR < 0.05)

	KEGG pathway	Size	ES	NES	FDR
Males	Protein Export	15	−0.60	0.000	0.001
	Proteasome	33	−0.37	0.000	0.002
	Antigen Processing and Presentation	20	−0.43	0.000	0.006
	Rna Degradation	16	−0.38	0.012	0.116
	Aminoacyl Trna Biosynthesis	19	−0.30	0.031	0.310
	Ppar Signaling Pathway	29	0.43	0.000	0.000
	Glycolysis Gluconeogenesis	21	0.48	0.000	0.001
	Drug Metabolism Cytochrome P450	20	0.44	0.000	0.006
	Glycine Serine and Threonine Metabolism	22	0.38	0.002	0.034
	Peroxisome	48	0.26	0.000	0.028
	Retinol Metabolism	16	0.43	0.006	0.031
	Citrate Cycle Tca Cycle	20	0.37	0.002	0.037
	Metabolism Of Xenobiotics By Cytochrome P450	17	0.41	0.006	0.033
Females	Cytokine Cytokine Receptor Interaction	94	−0.21	0.000	0.019
	Pathogenic Escherichia coli Infection	35	0.40	0.000	0.001
	Proteasome	34	0.37	0.000	0.003
	Amino Sugar and Nucleotide Sugar Metabolism	36	0.33	0.000	0.009
	Glycolysis Gluconeogenesis	33	0.34	0.000	0.017
	Ecm Receptor Interaction	55	0.25	0.000	0.022
	Cysteine and Methionine Metabolism	25	0.35	0.004	0.037
	Protein Export	19	0.39	0.002	0.047

Size = Number of genes. ES Enrichment score. ES represents the overepresentation degree of top and bottom genes included in ranked list based on log2FoldChange of DE genes included. NES Normalized enrichment score

ISSN: 1471-2164