Fig. 2

Identification of P. falciparum genes responsible for parasitizing human erythrocytes. a Heat map showing the clusters enriched in human and malaria parasites. Green, black, and red indicate cluster values equal to zero, one, and higher than one, respectively. b Bar plot displaying the genomic location of 115 P. falciparum genes and 267 P. berghei genes. Proximity to telomeres and proximity to centromeres refer to the genome regions within 40 kb away from telomeres and 10 kb away from centromeres, respectively. The rest of the genome was referred to as the chromosome internal region. The numbers in each parenthesis represent the number of genes and the percentage to human or malaria enriched genes. c Venn diagram showing the number of P. falciparum genes (upper panel) or P. berghei genes (lower panel) whose proteins contain a signal peptide, a transmembrane domain, or a PEXEL motif. d Domain models of SURFIN family members. Domains were identified through CD-search (https://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi) with a cut-off value of 0.01. TM domain stands for transmembrane domain