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Fig. 7 | BMC Genomics

Fig. 7

From: Successful application of human-based methyl capture sequencing for methylome analysis in non-human primate models

Fig. 7

Schematic of the procedures for genome-wide DNA methylation analysis. 1) Fragmentation of genomic DNA by sonication or restriction enzyme digestion. 2) Target genomic DNA enrichment using MBD protein, methylation antibody, or target probe. 3) Bisulfite conversion or 4) direct genome-wide DNA methylation analysis by microarray or a next-generation sequencing platform. MBD, methyl-CpG-binding domain; MeDIP, methylated DNA immunoprecipitation; Infinium or HM450, Illumina, Infinium Human Methylation 450 BeadChips; RRBS, reduced-representation-bisulfite-sequencing; MC-seq, methyl-capture sequencing; WGBS, whole-genome bisulfite sequencing

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