Table 1 circRNA-miRNA-mRNA network elements for those circRNA-miRNA interactions predicted by both miRanda and RNAHybrid, with a miRanda match score > = 180 and mRNA targets that are differentially expressed (uncorrected P < 0.05) with log2(fold change) >= 2 or =< − 2 (high stringency network)
Circular RNA | microRNA target | Number of binding sites predicted | Target genes (differentially expressed) |
|---|---|---|---|
X:47,431,299–48,327,824 | hsa-miR-139-5p | 6 | NOTCH1, STAMBP, TPD52 |
8:144,989,320–145,838,888 | hsa-miR-320a | 2 | METTL7A, PBX3, PLS1, SEC14L1, VCL, VIM, VOPP1, YPEL2 |
8:144,989,320–145,838,888 | hsa-miR-320b | 2 | RTKN, VCL, VOPP1 |
X:47,431,299–48,327,824 | hsa-miR-449a | 1 | BAZ2A, MFSD8, NOTCH1, TSN, ZNF551 |
8:144,989,320–145,838,888 | hsa-miR-125a-3p | 1 | ANKRD62, C15orf40, COL18A1, MFSD11, MPEG1, MUL1, TTC31, WDR12, ZNF641 |
X:47,431,299–48,327,824 | hsa-miR-125a-5p | 1 | CD34, MEGF9, PANX1, RIT1, TP53INP1 |
8:144,989,320–145,838,888 | hsa-miR-125a-5p | 1 | CD34, MEGF9, PANX1, RIT1, TP53INP1 |
X:47,431,299–48,327,824 | hsa-miR-324-5p | 1 | FOXO1, MEMO1, PSMD4, SMARCD2 |
14:23,815,526–24,037,279 | hsa-miR-142-3p | 1 | BTBD7, CLDN12, CPEB2, CSRP2, DAG1, KIF5B, PTPN23, WHAMM |
4:88,394,487–89,061,166 | hsa-miR-133b | 1 | FAM160B1 |
4:88,394,487–89,061,166 | hsa-miR-448 | 1 | DDIT4, PURG |
4:88,394,487–89,061,166 | hsa-miR-339-5p | 1 | AXL, HLA-E, METTL7A, ZNF285, ZNRF3 |