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Table 1 Top15 enriched gene sets in BEAS-2B cells after 20 h of exposure to UFP from diesel and biomass (FDR ≤ 0.05). Gene sets are from the of the MSigDB hallmarks collection; size is the number of genes in the gene set and NES, the normalized enrichment score, accounts for the overrepresentation of a gene set at the top or bottom of a ranked list of genes. Positive NES indicates enrichment in treated samples, instead negative NES in controls

From: Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles

Gene set Size NES
Enriched in BEAS-2B cells exposed to diesel UFP
 TNFA_SIGNALING_VIA_NFKB 182 4.635
 P53_PATHWAY 185 3.383
 HYPOXIA 168 3.145
 EPITHELIAL_MESENCHYMAL_TRANSITION 173 3.063
 XENOBIOTIC_METABOLISM 141 2.814
 COAGULATION 80 2.723
 ESTROGEN_RESPONSE_EARLY 166 2.645
 CHOLESTEROL_HOMEOSTASIS 70 2.411
 REACTIVE_OXIGEN_SPECIES_PATHWAY 43 2.389
 GLYCOLYSIS 174 2.318
 INFLAMMATORY_RESPONSE 127 2.272
 APICAL_JUNCTION 150 2.270
 G2M_CHECKPOINT 197 −2.819
 PROTEIN_SECRETION 92 −3.075
 E2F_TARGETS 199 −3.502
Enriched in BEAS-2B cells exposed to biomass UFP
 HYPOXIA 168 2.920
 MTORC1_SIGNALING 194 2.555
 PROTEIN_SECRETION 92 2.534
 TNFA_SIGNALING_VIA_NFKB 182 2.363
 FATTY_ACID_METABOLISM 130 2.350
 ANDROGEN_RESPONSE 89 2.337
 G2M_CHECKPOINT 197 2.335
 E2F_TARGETS 199 2.330
 INTERFERON_GAMMA_RESPONSE 158 2.263
 MYC_TARGETS_V1 198 2.222
 INFLAMMATORY_RESPONSE 127 2.115
 BILE_ACID_METABOLISM 76 2.080
 COMPLEMENT 139 2.049
 TGF_BETA_SIGNALING 50 1.875
 MYOGENESIS 123 −2.445