Table 1 Top15 enriched gene sets in BEAS-2B cells after 20 h of exposure to UFP from diesel and biomass (FDR ≤ 0.05). Gene sets are from the of the MSigDB hallmarks collection; size is the number of genes in the gene set and NES, the normalized enrichment score, accounts for the overrepresentation of a gene set at the top or bottom of a ranked list of genes. Positive NES indicates enrichment in treated samples, instead negative NES in controls
Gene set | Size | NES |
|---|---|---|
Enriched in BEAS-2B cells exposed to diesel UFP | ||
 TNFA_SIGNALING_VIA_NFKB | 182 | 4.635 |
 P53_PATHWAY | 185 | 3.383 |
 HYPOXIA | 168 | 3.145 |
 EPITHELIAL_MESENCHYMAL_TRANSITION | 173 | 3.063 |
 XENOBIOTIC_METABOLISM | 141 | 2.814 |
 COAGULATION | 80 | 2.723 |
 ESTROGEN_RESPONSE_EARLY | 166 | 2.645 |
 CHOLESTEROL_HOMEOSTASIS | 70 | 2.411 |
 REACTIVE_OXIGEN_SPECIES_PATHWAY | 43 | 2.389 |
 GLYCOLYSIS | 174 | 2.318 |
 INFLAMMATORY_RESPONSE | 127 | 2.272 |
 APICAL_JUNCTION | 150 | 2.270 |
 G2M_CHECKPOINT | 197 | −2.819 |
 PROTEIN_SECRETION | 92 | −3.075 |
 E2F_TARGETS | 199 | −3.502 |
Enriched in BEAS-2B cells exposed to biomass UFP | ||
 HYPOXIA | 168 | 2.920 |
 MTORC1_SIGNALING | 194 | 2.555 |
 PROTEIN_SECRETION | 92 | 2.534 |
 TNFA_SIGNALING_VIA_NFKB | 182 | 2.363 |
 FATTY_ACID_METABOLISM | 130 | 2.350 |
 ANDROGEN_RESPONSE | 89 | 2.337 |
 G2M_CHECKPOINT | 197 | 2.335 |
 E2F_TARGETS | 199 | 2.330 |
 INTERFERON_GAMMA_RESPONSE | 158 | 2.263 |
 MYC_TARGETS_V1 | 198 | 2.222 |
 INFLAMMATORY_RESPONSE | 127 | 2.115 |
 BILE_ACID_METABOLISM | 76 | 2.080 |
 COMPLEMENT | 139 | 2.049 |
 TGF_BETA_SIGNALING | 50 | 1.875 |
 MYOGENESIS | 123 | −2.445 |